Prediction of conserved microRNAs from skin and mucosal human papillomaviruses

Gu, Wenyi, An, Jiyuan, Ye, Ping, Zhao, KongNan and Antonsson, Annika (2011) Prediction of conserved microRNAs from skin and mucosal human papillomaviruses. Archives of Virology, 156 7: 1161-1171. doi:10.1007/s00705-011-0974-3


Author Gu, Wenyi
An, Jiyuan
Ye, Ping
Zhao, KongNan
Antonsson, Annika
Title Prediction of conserved microRNAs from skin and mucosal human papillomaviruses
Journal name Archives of Virology   Check publisher's open access policy
ISSN 0304-8608
1432-8798
Publication date 2011-03-26
Sub-type Article (original research)
DOI 10.1007/s00705-011-0974-3
Volume 156
Issue 7
Start page 1161
End page 1171
Total pages 11
Place of publication Vienna, Austria
Publisher Springer
Collection year 2012
Language eng
Abstract Eight human papillomavirus (HPV) types including four cutaneousHPVtypes (HPV-5,HPV-8,HPV-20 and HPV-38) and four mucosal HPV types (HPV-6, HPV-11, HPV-16 and HPV-18) were selected for this miRNA study. Pre-miRNAs were predicted using a computer programme, and the conserved mature miRNAs were compared to currently known miRNAs. Predicted HPV miRNAs related to miR-466, -467 and -669 were common and specific to the mucosal HPV types. Northern blot hybridization confirmed a predicted miRNA in HPV-positive cervical cancer cell lines encoded by mucosal HPVs. HPV-38 was predicted to express an miRNA conserved to human let-7a and the expression of let-7a, in HPV-38- positive non-melanoma skin cancer (NMSC) biopsies was 10-fold higher than those with HPV-positive (for other types except HPV-38) and HPV-negativeNMSCs, suggesting that let-7a expression might be related to HPV-38 infection. Potential gene targets of the predicted miRNA that may aid HPV in infection and pathogenesis were also analysed.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Fri, 21 Oct 2011, 16:55:29 EST by Dr Wenyi Gu on behalf of Aust Institute for Bioengineering & Nanotechnology