Role of the ghrelin/obestatin balance in the regulation of neuroendocrine circuits controlling body composition and energy homeostasis

Epelbaum, Jacques, Bedjanui, Nawel, Dardennes, Roland, Feng, Dan Dan, Gardette, Robert, Grouselle, Dominique, Loudes, Catherine, Simon, Axelle, Tolle, Virginie, Yang, Seung Kwon and Zizzari, Philippe (2009) Role of the ghrelin/obestatin balance in the regulation of neuroendocrine circuits controlling body composition and energy homeostasis. Molecular and Cellular Endocrinology, 314 2: 244-247. doi:10.1016/j.mce.2009.08.026


Author Epelbaum, Jacques
Bedjanui, Nawel
Dardennes, Roland
Feng, Dan Dan
Gardette, Robert
Grouselle, Dominique
Loudes, Catherine
Simon, Axelle
Tolle, Virginie
Yang, Seung Kwon
Zizzari, Philippe
Title Role of the ghrelin/obestatin balance in the regulation of neuroendocrine circuits controlling body composition and energy homeostasis
Journal name Molecular and Cellular Endocrinology   Check publisher's open access policy
ISSN 0303-7207
1872-8057
Publication date 2009-09-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.mce.2009.08.026
Volume 314
Issue 2
Start page 244
End page 247
Total pages 4
Place of publication Shannon, Co. Clare Ireland
Publisher Elsevier Ireland
Language eng
Abstract Ghrelin and obestatin are two peptides isolated from the gastrointestinal tract and encoded by the same preproghrelin gene. They convey to the central nervous system informations concerning the nutritional status and/or the energy stores. Ghrelin, mostly acting through the GH secretagogue receptor GHS-R, is a potent GH secretagogue, an orexigenic peptide and a long-term regulator of energy homeostasis. Obestatin was initially described for its anorexigenic effects and its binding to the G protein-coupled receptor 39 (GPR39). However, the role of obestatin is still controversial and the nature of the obestatin receptor remains an open question. This review is focussed on the possible implication of the ghrelin/obestatin system in psychiatric diseases with particular emphasis on eating disorders.
Keyword Ghrelin
Obestatin
GHS-R1
GPR39
Eating disorders
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Special issue - Signal Transduction in Health and Disease

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: ERA 2012 Admin Only
School of Biomedical Sciences Publications
 
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Created: Fri, 21 Oct 2011, 15:48:46 EST by Dr Sean Seung-Kwon Yang on behalf of School of Biomedical Sciences