A localized negative genetic correlation constrains microevolution of coat color in wild sheep

Gratten, J., Wilson, A. J., McRae, A. F., Beraldi, D., Visscher, P. M., Pemberton, J. M. and Slate, J. (2008) A localized negative genetic correlation constrains microevolution of coat color in wild sheep. Science, 319 5861: 318-320. doi:10.1126/science.1151182


Author Gratten, J.
Wilson, A. J.
McRae, A. F.
Beraldi, D.
Visscher, P. M.
Pemberton, J. M.
Slate, J.
Title A localized negative genetic correlation constrains microevolution of coat color in wild sheep
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
1095-9203
Publication date 2008-01
Sub-type Article (original research)
DOI 10.1126/science.1151182
Volume 319
Issue 5861
Start page 318
End page 320
Total pages 3
Place of publication Washington, DC, United States
Publisher American Association for the Advancement of Science
Language eng
Abstract The evolutionary changes that occur over a small number of generations in natural populations often run counter to what is expected on the basis of the heritability of traits and the selective forces acting upon them. In Soay sheep, dark coat color is associated with large size, which is heritable and positively correlated with fitness, yet the frequency of dark sheep has decreased. This unexpected microevolutionary trend is explained by genetic linkage between the causal mutation underlying the color polymorphism and quantitative trait loci with antagonistic effects on size and fitness. As a consequence, homozygous dark sheep are large, but have reduced fitness relative to phenotypically indistinguishable dark heterozygotes and light sheep. This result demonstrates the importance of understanding the genetic basis of fitness variation when making predictions about the microevolutionary consequences of selection.
Keyword Tyrosinase related protein 1
Natural-populations
Soay sheep
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Fri, 21 Oct 2011, 14:52:33 EST by Jake Gratten on behalf of Queensland Brain Institute