No association between TPH2 gene polymorphisms and ADHD in a UK sample

Sheehan, Karen, Hawi. Ziarih, Gill, Michael and Kent, Lindsey (2007) No association between TPH2 gene polymorphisms and ADHD in a UK sample. Neuroscience Letters, 412 2: 105-107. doi:10.1016/j.neulet.2006.10.043


Author Sheehan, Karen
Hawi. Ziarih
Gill, Michael
Kent, Lindsey
Title No association between TPH2 gene polymorphisms and ADHD in a UK sample
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
1872-7972
Publication date 2007-01
Year available 2006
Sub-type Article (original research)
DOI 10.1016/j.neulet.2006.10.043
Volume 412
Issue 2
Start page 105
End page 107
Total pages 3
Place of publication Shannon, Co. Clare Ireland
Publisher Elsevier Ireland
Language eng
Abstract Tryptophan Hydroxylase 2 (TPH2) is the rate-limiting enzyme in the biosynthesis of serotonin which is exclusively expressed in the brain. Recent molecular studies reported significant association between markers mapped to TPH2 and psychiatric conditions including ADHD. We have examined four single nucleotide polymorphisms (SNPs) two of which (rs1843809, rs1386493) were reported to associate with ADHD in an Irish ADHD sample. Transmission disequilibrium analysis revealed no significant association between any of these markers and ADHD. Dividing by the sex of the transmitting parent has also failed to replicate the previously reported paternal over-transmission of the associated alleles to ADHD probands. A larger sample size will be required to clarify if TPH2 alleles are or are not associated with ADHD.
Keyword Attention Deficit Hyperactivity Disorder (ADHD)
Tryptophan Hydroxylase 2 (TPH2)
Transmission disequilibrium test (TDT)
Serotonergic system
Genetic association
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Fri, 21 Oct 2011, 14:14:55 EST by Ziarih Hawi on behalf of Queensland Brain Institute