Increased neural resources recruitment in the intrinsic organization in major depression

Zhou, Yuan, Yu, Chunshui, Zheng, Hua, Liu, Yong, Song, Ming, Qin, Wen, Li, Kuncheng and Jiang, Tianzi (2010) Increased neural resources recruitment in the intrinsic organization in major depression. Journal of Affective Disorders, 121 3: 220-230. doi:10.1016/j.jad.2009.05.029


Author Zhou, Yuan
Yu, Chunshui
Zheng, Hua
Liu, Yong
Song, Ming
Qin, Wen
Li, Kuncheng
Jiang, Tianzi
Title Increased neural resources recruitment in the intrinsic organization in major depression
Journal name Journal of Affective Disorders   Check publisher's open access policy
ISSN 0165-0327
1573-2517
Publication date 2010-03
Sub-type Article (original research)
DOI 10.1016/j.jad.2009.05.029
Volume 121
Issue 3
Start page 220
End page 230
Total pages 11
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
Objective

To investigate the functional connectivity (FC) pattern within an intrinsic functional organization, including both task-positive (TPN) and task-negative (TNN) networks, in major depressive disorder (MDD), and to examine relationships between the involved FCs and clinical variables.

Methods

Resting-state FC analyses were used to identify the component brain regions of the intrinsic organization and to investigate the FCs of the individual component regions in 18 first-episode, medication-naïve MDD and 20 healthy control subjects.

Results

We found that the intrinsic organization of the depressed group recruited more extensive regions than the control group. All of the altered FCs associated with the component regions increased in MDD. Specifically, in the TPN the increased FCs were primarily located in the bilateral lateral prefrontal cortices and the inferior parietal lobes, which have been implicated in attention and adaptive control. In the TNN, the increased FCs were primarily located in the posterior cingulate cortex and the medial orbitofrontal cortex, which are involved in episodic memory, self-reflection and emotional regulation. We also found increased anti-correlations between the two networks. Additionally, the strengths of the FCs associated with the lateral prefrontal cortices were found to be correlated with the duration of the depressive episode and the HDRS scores in the depressed patients.

Limitations

Clinical correlates of these abnormal FCs should be cautiously interpreted due to the small sample size in this study.

Conclusions

Abnormalities in the intrinsic organization may be an underlying basis for the pronounced and prolonged negative bias in processing emotional information observed in MDD.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Fri, 21 Oct 2011, 14:12:17 EST by Sylvie Pichelin on behalf of Queensland Brain Institute