Reduced prefrontal activation during Tower of London in first-episode schizophrenia: a multi-channel near-infrared spectroscopy study

Zhu, Ye, Liu, Xuan, Wang, Huiling, Jiang,Tianzi, Fang, Yue, Hu, Hanbin, Wang, Gaohua, Wang, Xioaping, Liu, Zhongchun and Zhang, Kai (2010) Reduced prefrontal activation during Tower of London in first-episode schizophrenia: a multi-channel near-infrared spectroscopy study. Neuroscience Letters, 478 3: 136-140. doi:10.1016/j.neulet.2010.05.003


Author Zhu, Ye
Liu, Xuan
Wang, Huiling
Jiang,Tianzi
Fang, Yue
Hu, Hanbin
Wang, Gaohua
Wang, Xioaping
Liu, Zhongchun
Zhang, Kai
Title Reduced prefrontal activation during Tower of London in first-episode schizophrenia: a multi-channel near-infrared spectroscopy study
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
1872-7972
Publication date 2010-07
Sub-type Article (original research)
DOI 10.1016/j.neulet.2010.05.003
Volume 478
Issue 3
Start page 136
End page 140
Total pages 5
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Language eng
Formatted abstract
Cognitive impairments are considered as a core feature of schizophrenia and have been reported in associated with dysfunction of the prefrontal cortex (PFC). The Tower of London (TOL) task is a widely used neuropsychological test to assess the planning ability and the PFC function. In the present study, we examined functional changes in the PFC of 40 first-episode schizophrenia patients and 40 age- and gender-matched healthy controls by means of multi-channel Near-infrared spectroscopy (NIRS) during performance of the TOL task. NIRS is a noninvasive optical method that can measure relative changes in oxygenated ([oxy-Hb]) and deoxygenated ([deoxy-Hb]) hemoglobin in cortical tissue. Compared to the healthy controls, schizophrenia patients exhibited a significant decreased activation in the left PFC and poorer TOL performance. The results confirm the functional deficits of the PFC and impaired planning ability in first-episode schizophrenia patients and suggest that NIRS may be a useful clinical tool for evaluating PFC activation in psychiatric disorders.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Fri, 21 Oct 2011, 14:02:47 EST by Sylvie Pichelin on behalf of Queensland Brain Institute