Dorsal visual pathway changes in patients with comitant extropia

Yan, Xiaohe, Lin, Xioaming, Wang, Qifeng, Zhang, Yuanchao, Chen, Yingming, Song, Shaojie and Jiang,Tianzi (2010) Dorsal visual pathway changes in patients with comitant extropia. PLoS One, 5 6: e10931 - 1-e10931 - 6. doi:10.1371/journal.pone.0010931


Author Yan, Xiaohe
Lin, Xioaming
Wang, Qifeng
Zhang, Yuanchao
Chen, Yingming
Song, Shaojie
Jiang,Tianzi
Title Dorsal visual pathway changes in patients with comitant extropia
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2010-06
Sub-type Article (original research)
DOI 10.1371/journal.pone.0010931
Open Access Status DOI
Volume 5
Issue 6
Start page e10931 - 1
End page e10931 - 6
Total pages 6
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Formatted abstract
Background

Strabismus is a disorder in which the eyes are misaligned. Persistent strabismus can lead to stereopsis impairment. The effect of strabismus on human brain is not unclear. The present study is to investigate whether the brain white structures of comitant exotropia patients are impaired using combined T1-weighted imaging and diffusion tensor imaging (DTI).

Principal Findings


Thirteen patients with comitant strabismus and twelve controls underwent magnetic resonance imaging (MRI) with acquisition of T1-weighted and diffusion tensor images. T1-weighted images were used to analyze the change in volume of white matter using optimized voxel-based morphology (VBM) and diffusion tensor images were used to detect the change in white matter fibers using voxel-based analysis of DTI in comitant extropia patients. VBM analysis showed that in adult strabismus, white matter volumes were smaller in the right middle occipital gyrus, right occipital lobe/cuneus, right supramarginal gyrus, right cingulate gyrus, right frontal lobe/sub-gyral, right inferior temporal gyrus, left parahippocampa gyrus, left cingulate gyrus, left occipital lobe/cuneus, left middle frontal gyrus, left inferior parietal lobule, and left postcentral gyrus, while no brain region with greater white matter volume was found. Voxel-based analysis of DTI showed lower fractional anisotropy (FA) values in the right middle occipital gyrus and right supramarginal gyrus in strabismus patients, while brain region with increased FA value was found in the right inferior frontal gyrus.

Conclusion

By combining VBM and voxel-based analysis of DTI results, the study suggests that the dorsal visual pathway was abnormal or impaired in patients with comitant exotropia.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article number e10931

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Fri, 21 Oct 2011, 13:51:14 EST by Sylvie Pichelin on behalf of Queensland Brain Institute