Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease

Xu, Cunlu, Wang, Zhenhua, Fan, Ming, Liu, Bing, Song, Ming, Zhen, Xiantong, Jiang, Tianzi and Alzheimer's Disease Neuroimaging Initiative (2010) Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease. Neuroreport, 21 12: 802-807. doi:10.1097/WNR.0b013e32833ccaf4


Author Xu, Cunlu
Wang, Zhenhua
Fan, Ming
Liu, Bing
Song, Ming
Zhen, Xiantong
Jiang, Tianzi
Alzheimer's Disease Neuroimaging Initiative
Title Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease
Journal name Neuroreport   Check publisher's open access policy
ISSN 0959-4965
1473-558X
Publication date 2010-08
Sub-type Article (original research)
DOI 10.1097/WNR.0b013e32833ccaf4
Volume 21
Issue 12
Start page 802
End page 807
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Earlier studies showed that the Val66Met polymorphisms of the brain-derived neurotrophic factor differentially affect gray matter volume and brain region activities. This study used resting positron emission tomography to investigate the relationship between the polymorphisms of Val66Met and the regional cerebral metabolic rate in the brain. We analyzed the positron emission tomography images of 215 patients from the Alzheimer's Disease Neuroimaging Initiative and found significant differences in the parahippocampal gyrus, superior temporal gyrus, prefrontal cortex, and inferior parietal lobule when comparing Met carriers with noncarriers among both the normal controls and those with mild cognitive impairment. For those with Alzheimer's disease, we also found additional differences in the bilateral insula between the carriers and noncarriers.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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Created: Fri, 21 Oct 2011, 13:46:56 EST by Sylvie Pichelin on behalf of Queensland Brain Institute