Cortical thickness is associated with different apolipoprotein E genotypes in healthy elderly adults

Fan, Ming, Liu, Bing, Zhou, Yuan, Zhen, Xiantong, Xu, Xiantong, Jiang, Tianzi and Alzheimer's Disease Neuroimaging Inititative (2010) Cortical thickness is associated with different apolipoprotein E genotypes in healthy elderly adults. Neuroscience Letters, 479 3: 332-336. doi:10.1016/j.neulet.2010.05.092


Author Fan, Ming
Liu, Bing
Zhou, Yuan
Zhen, Xiantong
Xu, Xiantong
Jiang, Tianzi
Alzheimer's Disease Neuroimaging Inititative
Title Cortical thickness is associated with different apolipoprotein E genotypes in healthy elderly adults
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
1872-7972
Publication date 2010-08-02
Sub-type Article (original research)
DOI 10.1016/j.neulet.2010.05.092
Volume 479
Issue 3
Start page 332
End page 336
Total pages 5
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier Ireland
Language eng
Formatted abstract
Previous studies have consistently suggested that the ɛ4 allele of apolipoprotein E (APOE) gene is a major risk factor for Alzheimer's disease (AD). However, whether the ɛ2 allele, a possible protective factor for AD, will express its protective effect in terms of cortical thickness in healthy elderly carriers is unclear. The goal of this study is to clarify the effects of APOE genotypes on cortical thickness in nondemented elderly subjects. We used 164 healthy, cognitively normal, elderly subjects, who were grouped into ɛ2 carriers, ɛ3 homozygotes, and ɛ4 carriers respectively. The APOE ɛ2 carriers had a significant thicker (corrected p < 0.05) cortical thickness in the superior temporal cortex compared with the ɛ3 homozygotes. In addition to this area, the APOE ɛ2 carriers had a significantly thicker region in the dorsolateral prefrontal cortex (corrected p < 0.05) than did the ɛ4 carriers. These findings suggest that the different alleles of the APOE gene have distinct neuroanatomic effects in elderly healthy subjects and may play specific roles in the development of AD.
Keyword Cortical thickness
Apolipoprotein E
Alzheimer's disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
ERA 2012 Admin Only
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 21 Oct 2011, 13:42:53 EST by Sylvie Pichelin on behalf of Queensland Brain Institute