Abnormal integrity of long association fiber tracts is associated with cognitive deficits in patients with remitted geriatric depression: A cross-sectional, case-control study

Yuan, Yonggui, Hou, Zhenghua, Zhang, Zhijun, Bai, Feng, You, Jiayong, Shi, Yongmei, Liu, Wen and Jiang, Tianzi (2010) Abnormal integrity of long association fiber tracts is associated with cognitive deficits in patients with remitted geriatric depression: A cross-sectional, case-control study. Journal of Clinical Psychiatry, 71 10: 1386-1390. doi:10.4088/JCP.09m05313gry


Author Yuan, Yonggui
Hou, Zhenghua
Zhang, Zhijun
Bai, Feng
You, Jiayong
Shi, Yongmei
Liu, Wen
Jiang, Tianzi
Title Abnormal integrity of long association fiber tracts is associated with cognitive deficits in patients with remitted geriatric depression: A cross-sectional, case-control study
Journal name Journal of Clinical Psychiatry   Check publisher's open access policy
ISSN 0160-6689
1555-2101
1096-0104
Publication date 2010-10
Sub-type Article (original research)
DOI 10.4088/JCP.09m05313gry
Volume 71
Issue 10
Start page 1386
End page 1390
Total pages 5
Place of publication Memphis, TN, United States
Publisher Physicians Postgraduate Press
Language eng
Formatted abstract
Objective: The aim of this study was to explore the integrity of association fiber tracts of the interhemispheric and within-hemispheric communication in patients with remitted geriatric depression (RGD) by diffusion tensor imaging.
Method: A region of interest-based diffusion tensor imaging approach was applied to explore fiber tract differences between 37 patients with DSM-IV-diagnosed RGD and 33 well-matched, normal, aging healthy controls. Correlations were also sought between fractional anisotropy values and cognitive performance scores in the patients with RGD. The patients were recruited from January 2007 to December 2007.
Results: Extensive impairment of the integrity of association fiber tracts was observed in patients with RGD, including in the bilateral inferior frontooccipital fascicles, genu of corpus callosum, and posterior cingulate bundles. In addition, the fractional anisotropy value of left posterior cingulate bundles displayed a significantly negative correlation with the performance (time) of Trail-Making Test A (r = -0.383, P = .019).
Conclusions: This study suggested that association fiber tracts between remote cortexes may yield important new clues to predict whether a patient will eventually develop Alzheimer's disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Fri, 21 Oct 2011, 13:28:38 EST by Sylvie Pichelin on behalf of Queensland Brain Institute