Multiple melanoma susceptibility factors function in an ultraviolet radiation response pathway in skin

Giles, N., Pavey, S., Pinder, A. and Gabrielli, B. (2012) Multiple melanoma susceptibility factors function in an ultraviolet radiation response pathway in skin. British Journal of Dermatology, 166 2: 362-371. doi:10.1111/j.1365-2133.2011.10635.x


Author Giles, N.
Pavey, S.
Pinder, A.
Gabrielli, B.
Title Multiple melanoma susceptibility factors function in an ultraviolet radiation response pathway in skin
Journal name British Journal of Dermatology   Check publisher's open access policy
ISSN 0007-0963
1365-2133
Publication date 2012-02
Year available 2011
Sub-type Article (original research)
DOI 10.1111/j.1365-2133.2011.10635.x
Volume 166
Issue 2
Start page 362
End page 371
Total pages 10
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2012
Language eng
Formatted abstract
Exposure to ultraviolet radiation (UVR) and the familial melanoma susceptibility gene p16INK4A are among the major risk factors which have been identified to contribute to the development of melanoma, and also significantly contribute to squamous cell carcinoma. Previously, we have shown that UVR induces p16INK4A the expression in melanoma and keratinocyte cell lines and human skin, but the regulatory mechanisms controlling this expression was unknown. Here we show that UVR induced ERK signalling, mediated by BRAF, regulates p16INK4A expression at the transcriptional, and possibly translational level. This study demonstrates the biological connection between the known melanoma genes, p16INK4A and BRAF in a normal physiological response to UVR in the skin, and highlights the importance of defects in this biological pathway to melanoma and squamous cell carcinoma development.
Keyword UVR
Melanocyte
p16INK4A
BRAF
ERK
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 21 Oct 2011, 11:43:14 EST by Dr Sandra Pavey on behalf of UQ Diamantina Institute