Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls

Wang, Fei, Jiang, Tianzi, Sun, Zhiguo, Teng, Siew-leng, Luo, Xingguang, Zhu, Zhongjun, Zang, Yufeng, Zhang, Handi, Yue, Weihua, Qu, Mei, Lu, Tianlan, Hong, Nan, Huang, Haiyan, Blumberg, Hilary P. and Zhang, Dai (2009) Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls. Journal of Psychiatry and Neuroscience, 34 3: 181-186.

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Author Wang, Fei
Jiang, Tianzi
Sun, Zhiguo
Teng, Siew-leng
Luo, Xingguang
Zhu, Zhongjun
Zang, Yufeng
Zhang, Handi
Yue, Weihua
Qu, Mei
Lu, Tianlan
Hong, Nan
Huang, Haiyan
Blumberg, Hilary P.
Zhang, Dai
Title Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls
Journal name Journal of Psychiatry and Neuroscience   Check publisher's open access policy
ISSN 1180-4882
1488-2434
Publication date 2009-05
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 34
Issue 3
Start page 181
End page 186
Total pages 6
Place of publication Ottawa, Canada
Publisher Canadian Medical Association
Language eng
Formatted abstract
Background: Neuregulin1 (NRG1) influences the development of white matter connectivity and is implicated in genetic susceptibility to schizophrenia. The cingulum bundle is a white matter structure implicated in schizophrenia. Its anterior component is especially implicated, as it provides reciprocal connections between brain regions with prominent involvement in the disorder. Abnormalities in the structural integrity of the anterior cingulum in patients with schizophrenia have been reported previously. The present study investigated the potential contribution of NRG1 variation to anterior cingulum abnormalities in participants with schizophrenia.
Methods: We studied 31 men with schizophrenia and 36 healthy men using diffusion tensor imaging to investigate the association between fractional anisotropy in the anterior cingulum and a single-nucleotide polymorphism (SNP8NRG221533: rs35753505) of NRG1.
Results: Consistent with previous reports, fractional anisotropy was significantly reduced in the anterior cingulum in the schizophrenia group. Moreover, the results revealed a significant group (schizophrenia, control) by genotype (C/C, T carriers, including CT and TT) interaction between genetic variation in NRG1 and diagnosis of schizophrenia, such that the patients with the T allele for SNP8NRG221533 had significantly decreased anterior cingulum fractional anisotropy compared with patients homozygous for the C allele and healthy controls who were T carriers.
Limitations: Limitations of our study included the small sample size of the TT subgroup and our use of only fractional anisotropy as an index of myelin integrity. In addition, the use of diffusion tensor imaging acquisition methods limited our ability to study other brain regions that may be involved in schizophrenia.
Conclusion: Our results suggest that NRG1 variation may play a role in the pathophysiology of anterior cingulum abnormalities in patients with schizophrenia.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Fri, 21 Oct 2011, 11:04:03 EST by Debra McMurtrie on behalf of Queensland Brain Institute