COMT val158met modulates association between brain white matter architecture and IQ

Li, Jun, Yu, Chunshui, Li, Yonghui, Liu, Bing, Liu, Yong, Shu, Ni, Song, Ming, Zhou, Yuan, Zhu, Wanlin, Li, Kuncheng and Jiang, Tianzi (2009) COMT val158met modulates association between brain white matter architecture and IQ. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 150B 3: 375-380. doi:10.1002/ajmg.b.30825


Author Li, Jun
Yu, Chunshui
Li, Yonghui
Liu, Bing
Liu, Yong
Shu, Ni
Song, Ming
Zhou, Yuan
Zhu, Wanlin
Li, Kuncheng
Jiang, Tianzi
Title COMT val158met modulates association between brain white matter architecture and IQ
Journal name American Journal of Medical Genetics Part B: Neuropsychiatric Genetics   Check publisher's open access policy
ISSN 1552-4841
1552-485X
Publication date 2009-04-05
Year available 2008
Sub-type Article (original research)
DOI 10.1002/ajmg.b.30825
Volume 150B
Issue 3
Start page 375
End page 380
Total pages 6
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract The intelligence quotient (IQ) is typically associated with the architecture of gray and white matter in specific brain regions, and this association appears to be genetically based. However, specific sources of genetic variation for the association have not been studied extensively. Using diffusion tensor imaging in 15 mental retardation patients and 80 healthy volunteers, we studied the association between white matter architecture and IQ and also investigated the effects of COMT val158met on this association. The results showed that fractional anisotropy (FA) values in the prefrontal lobe and the hippocampus formation were associated with IQ and that val158met may affect this association. Subjects who were val homozygous showed steeper slopes for regression of the FA value on IQ than met carriers. Our findings suggest that COMT val158met may contribute to intelligence by affecting the association between IQ and the white matter architecture in the prefrontal lobe and the hippocampal formation.
Keyword Catechol-o-methyltransferase
Dopamine
Intelligence
Diffusion tensor imaging
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 9 JUL 2008

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Fri, 21 Oct 2011, 20:34:04 EST by Debra McMurtrie on behalf of Queensland Brain Institute