Abnormal diffusion of cerebral white matter in early blindness

Shu, Ni, Li, Jun, Li, Kuncheng, Yu, Chunshui and Jiang, Tianzi (2009) Abnormal diffusion of cerebral white matter in early blindness. Human Brain Mapping, 30 1: 220-227. doi:10.1002/hbm.20507


Author Shu, Ni
Li, Jun
Li, Kuncheng
Yu, Chunshui
Jiang, Tianzi
Title Abnormal diffusion of cerebral white matter in early blindness
Journal name Human Brain Mapping   Check publisher's open access policy
ISSN 1065-9471
1097-0193
Publication date 2009-01
Year available 2007
Sub-type Article (original research)
DOI 10.1002/hbm.20507
Volume 30
Issue 1
Start page 220
End page 227
Total pages 8
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Early visual deprivation may lead to both abnormal and plastic changes in the visual and other systems of the brain. Such secondary changes in the gray matter of the early blind have been well studied, but not so well in the cerebral white matter whose subtle changes may be revealed by diffusion tensor imaging. The first purpose of this study is to explore the possible changed white matter regions of the early blind in whole brain manners, using voxel-based analysis (VBA) and tract-based spatial statistics (TBSS) methods. The second purpose is to investigate the changes of diffusion eigenvalues in the abnormal white matter fiber tracts using tractography based group mapping analysis. From VBA of fractional anisotropy (FA) images, the significant changed white matter regions were the geniculocalcarine tract (GCT) and its adjacent regions. This finding was validated by TBSS method. Then we studied the changes of mean diffusivity (MD), FA, primary (λ1) and transverse diffusivities (λ23) in the GCT using tractography based group mapping analysis. We found the early blind had significantly lower FA (P < 0.0001), higher MD (P = 0.001) and λ23 (P < 0.0001) in the GCT. This pattern of diffusion changes is similar to findings seen in immaturity or axonal degeneration. Thus, we suggest that transneuronal degeneration and/or immaturity may account for the abnormal diffusion changes in the GCT of the early blind. Hum Brain Mapp 2009.
Keyword Early blind
Diffusion tensor imaging
Tractography
Visual system
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 10 DEC 2007

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Fri, 21 Oct 2011, 10:18:32 EST by Debra McMurtrie on behalf of Queensland Brain Institute