Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): Analysis of data from the international multicenter ADHD genetics (IMAGE) program

Anney, Richard J. L., Hawi, Ziarih, Sheehan, Karen, Mulligan, Aisling, Pinto, Carlos, Brookes, Keeley J., Xu, Xiaohui, Zhou, Kaixin, Franke, Barbara, Buitelaar, Jan, Vermeulen, Sita H., Banaschewski, Tobias, Sonuga-Barke, Edmund, Ebstein, Richard, Manor, Iris, Miranda, Ana, Mulas, Fernando, Oades, Robert D., Roeyers, Herbert, Rommelse, Nanda, Rothenberger, Aribert, Sergeant, Joseph, Steinhausen, Hans-Christoph, Taylor, Eric, Thompson, Margaret, Asherson, Philip, Faraone, Stephen V. and Gill, Michael (2008) Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): Analysis of data from the international multicenter ADHD genetics (IMAGE) program. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B 8: 1495-1500. doi:10.1002/ajmg.b.30659


Author Anney, Richard J. L.
Hawi, Ziarih
Sheehan, Karen
Mulligan, Aisling
Pinto, Carlos
Brookes, Keeley J.
Xu, Xiaohui
Zhou, Kaixin
Franke, Barbara
Buitelaar, Jan
Vermeulen, Sita H.
Banaschewski, Tobias
Sonuga-Barke, Edmund
Ebstein, Richard
Manor, Iris
Miranda, Ana
Mulas, Fernando
Oades, Robert D.
Roeyers, Herbert
Rommelse, Nanda
Rothenberger, Aribert
Sergeant, Joseph
Steinhausen, Hans-Christoph
Taylor, Eric
Thompson, Margaret
Asherson, Philip
Faraone, Stephen V.
Gill, Michael
Title Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): Analysis of data from the international multicenter ADHD genetics (IMAGE) program
Journal name American Journal of Medical Genetics Part B: Neuropsychiatric Genetics   Check publisher's open access policy
ISSN 1552-4841
1552-485X
Publication date 2008-12-05
Year available 2007
Sub-type Article (original research)
DOI 10.1002/ajmg.b.30659
Volume 147B
Issue 8
Start page 1495
End page 1500
Total pages 6
Editor Benjamin M. Neale
Stephen V. Faraone
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and gene-specific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested by Chi-square. There was no overall parent of origin effect in the IMAGE sample (χ12 = 1:82, P = 0.117). Five markers in three genes, DDC, TPH2, and SLC6A2 showed nominal association (P < 0.01) with ADHD combined subtype when restricted to maternal or paternal transmission only. Following the initial report by Hawi and co-workers three studies, including this one, found no evidence to support an overall parent of origin effect for markers associated with ADHD. We cannot however, exclude gene-specific parent of origin effect in the etiology ADHD.
Keyword ADHD
Candidate gene
Parent of origin effect
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 28 DEC 2007. Special Issue on the Genetics of ADHD Dedicated to the Memory of Richard Todd.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Thu, 20 Oct 2011, 18:37:37 EST by Ziarih Hawi on behalf of Queensland Brain Institute