fMRI activation during response inhibition and error processing: The role of the DAT1 gene in typically developing adolescents and those diagnosed with ADHD

Braet, Wouter, Johnson, Katherine A., Tobin, Claire T., Acheson, Ruth, McDonnell, Caroline, Hawi, Ziarah, Barry, Edwina, Mulligan, Aisling, Gill, Michael, Bellgrove, Mark A., Robertson, Ian H. and Garavan, Hugh (2011) fMRI activation during response inhibition and error processing: The role of the DAT1 gene in typically developing adolescents and those diagnosed with ADHD. Neuropsychologia, 49 7: 1641-1650. doi:10.1016/j.neuropsychologia.2011.01.001

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Braet, Wouter
Johnson, Katherine A.
Tobin, Claire T.
Acheson, Ruth
McDonnell, Caroline
Hawi, Ziarah
Barry, Edwina
Mulligan, Aisling
Gill, Michael
Bellgrove, Mark A.
Robertson, Ian H.
Garavan, Hugh
Title fMRI activation during response inhibition and error processing: The role of the DAT1 gene in typically developing adolescents and those diagnosed with ADHD
Journal name Neuropsychologia   Check publisher's open access policy
ISSN 0028-3932
1873-3514
Publication date 2011-06
Sub-type Article (original research)
DOI 10.1016/j.neuropsychologia.2011.01.001
Volume 49
Issue 7
Start page 1641
End page 1650
Total pages 10
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2012
Language eng
Abstract The DAT1 gene codes for the dopamine transporter, which clears dopamine from the synaptic cleft, and a variant of this gene has previously been associated with compromised response inhibition in both healthy and clinical populations. This variant has also been associated with ADHD, a disorder that is characterised by disturbed dopamine function as well as problems with response inhibition. In the present study we used fMRI to investigate the role of dopaminergic genetic variation on executive functioning by comparing how activation associated with successful and unsuccessful inhibitions differs based on DAT1-genotype and ADHD-diagnosis in adolescents performing a go/nogo task. The results identify regional specificity concerning which functional differences can be attributed to the possession of the high risk DAT1 genotype, the clinical condition or an interaction between the two. During response inhibition, individuals with two copies of the 10-repeat allele showed increased activation in frontal, medial, and parietal regions, which may indicate that inhibition is more effortful for this group. Conversely, this group displayed a reduced error response in the parahippocampal gyrus, suggestive of reduced learning from errors. There were also a number of frontal, parietal, medial and occipital regions, where the relationship between genotype and fMRI-activation differed between the ADHD group and the typically developing adolescents. Finally, the ADHD group displayed decreased activation in parietal and (pre)frontal regions during response inhibition, and in frontal and medial brain regions on error trials.
Keyword Response inhibition
fMRI
Endophenotype
DAT1
Dopamine
Error processing
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
School of Psychology Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 20 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 23 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 20 Oct 2011, 17:50:49 EST by Ziarih Hawi on behalf of Queensland Brain Institute