Dopamine gates action potential backpropagation in midbrain dopaminergic neurons

Gentet, Luc J. and Williams, Stephen R. (2007) Dopamine gates action potential backpropagation in midbrain dopaminergic neurons. Journal of Neuroscience, 27 8: 1892-1901. doi:10.1523/JNEUROSCI.5234-06.2007

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Author Gentet, Luc J.
Williams, Stephen R.
Title Dopamine gates action potential backpropagation in midbrain dopaminergic neurons
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2007-02-21
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.5234-06.2007
Open Access Status File (Publisher version)
Volume 27
Issue 8
Start page 1892
End page 1901
Total pages 10
Place of publication Washington, DC, United States
Publisher Society for Neuroscience
Language eng
Abstract Dopamine is released from both axonal and somatodendritic sites of midbrain dopaminergic neurons in an action potential-dependent manner. In contrast to the majority of central neurons, the axon of dopaminergic neurons typically originates from a dendritic site, suggesting a specialized computational function. Here, we examine the initiation and spread of action potentials in dopaminergic neurons of the substantia nigra pars reticulata and reveal that the displacement of the axon to a dendritic site allows highly compartmentalized electrical signaling. In response to a train of synaptic input, action potentials initiated at axon-bearing dendritic sites formed a variable trigger for invasion to the soma and contralateral dendritic tree, with action potentials often confined to the axon-bearing dendrite. The application of dopamine increased this form of electrical compartmentalization, an effect mediated by a tonic membrane potential hyperpolarization leading to an increased availability of a class of voltage-dependent potassium channel. These data suggest that the release of dopamine from axonal and somatodendritic sites are dissociable, and that dopamine levels within the midbrain are dynamically controlled by the somatodendritic spread of action potentials.
Keyword EPSP
Action potential
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 20 Oct 2011, 17:34:14 EST by Stephen Williams on behalf of Queensland Brain Institute