Selective determination of norepinephrine in the presence of ascorbic and uric acids using an ultrathin polymer film modified electrode

Kalimuthu, Palraj and John, S. Abraham (2011) Selective determination of norepinephrine in the presence of ascorbic and uric acids using an ultrathin polymer film modified electrode. Electrochimica Acta, 56 5: 2428-2432. doi:10.1016/j.electacta.2010.11.043


Author Kalimuthu, Palraj
John, S. Abraham
Title Selective determination of norepinephrine in the presence of ascorbic and uric acids using an ultrathin polymer film modified electrode
Journal name Electrochimica Acta   Check publisher's open access policy
ISSN 0013-4686
1873-3859
Publication date 2011-02
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.electacta.2010.11.043
Volume 56
Issue 5
Start page 2428
End page 2432
Total pages 5
Place of publication Kidlington, United Kingdom
Publisher Pergamon
Collection year 2011
Language eng
Formatted abstract
This paper reports the selective determination of norepinephrine (NEP) in the presence of very important interferences, ascorbic acid (AA) and uric acid (UA) using electropolymerized film of 2-amino-1,3,4-thiadiazole (p-ATD) modified glassy carbon (GC) electrode in 0.20M phosphate buffer solution (pH 5.0). The bare GC electrode does not separate the voltammetric signals of AA, NEP and UA. However, p-ATD modified GC electrode not only resolved the voltammetric signals of AA, NEP and UA with potential differences of 150 and 130mV between AA–NEP and NEP–UA, respectively but also dramatically enhanced the oxidation peak currents of them when compared to bare GC electrode. The modified electrode showed an excellent selectivity towards NEP even in the presence of 100-fold excess of AA and UA. The amperometric current was linearly increased from 40nM to 25µM for NEP and the lowest detection limit was found to be 0.17nM (S/N = 3). The practical application of the modified electrode was demonstrated by determining NEP in norepinephrine hydrochloride injection.
Keyword 2-Amino-1,3,4-thiadiazole
Electropolymerization
Norepinephrine
Ascorbic acid
Uric acid
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ
Additional Notes Available online 21 November 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Chemistry and Molecular Biosciences
 
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