Recombination rates of human microRNA

Zhaoa, Huizhi, Wang, Dong, Liu, Bing, Jiang, Xingpeng, Zhang, Jing, Fan, Ming, Fan, Zhengjie, Chen, Ying, Song, Sonya Wei, Gao, Wei, Jiang, Tianzi and Cui, Qinghua (2009) Recombination rates of human microRNA. Biochemical and Biophysical Research Communications, 379 3: 702-705. doi:10.1016/j.bbrc.2008.12.144

Author Zhaoa, Huizhi
Wang, Dong
Liu, Bing
Jiang, Xingpeng
Zhang, Jing
Fan, Ming
Fan, Zhengjie
Chen, Ying
Song, Sonya Wei
Gao, Wei
Jiang, Tianzi
Cui, Qinghua
Title Recombination rates of human microRNA
Journal name Biochemical and Biophysical Research Communications   Check publisher's open access policy
ISSN 0006-291X
Publication date 2009-01-06
Sub-type Article (original research)
DOI 10.1016/j.bbrc.2008.12.144
Volume 379
Issue 3
Start page 702
End page 705
Total pages 4
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Formatted abstract
The fact that microRNAs play a role in almost all biological processes is well established, as is the importance of recombination in generating genome variability. However, the association between microRNAs and recombination remains largely unknown. In order to investigate the recombination patterns of microRNAs, we performed a comprehensive analysis of the recombination rate of human microRNAs. We observed that microRNAs that are expressed in several tissues tend to have lower recombination rates than tissue-specific microRNAs. Additionally, microRNAs that are associated with a number of diseases are also likely to have lower recombination rates. Furthermore, microRNAs with higher expression levels are found to have fewer recombination events. These findings reveal patterns in recombination rates of microRNAs that could help in understanding the function, evolution, and disease-related roles of microRNAs.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Thu, 20 Oct 2011, 16:04:04 EST by Debra McMurtrie on behalf of Queensland Brain Institute