Altered functional connectivity of primary visual cortex in early blindness

Yu, Chunshui, Liu, Yong, Li, Jun, Zhou, Yuan, Wang, Kun, Tian, Lixia, Qin, Wen, Jiang, Tianzi and Li, Kuncheng (2008) Altered functional connectivity of primary visual cortex in early blindness. Human Brain Mapping, 29 5: 533-543. doi:10.1002/hbm.20420


Author Yu, Chunshui
Liu, Yong
Li, Jun
Zhou, Yuan
Wang, Kun
Tian, Lixia
Qin, Wen
Jiang, Tianzi
Li, Kuncheng
Title Altered functional connectivity of primary visual cortex in early blindness
Journal name Human Brain Mapping   Check publisher's open access policy
ISSN 1065-9471
1097-0193
Publication date 2008-05
Year available 2007
Sub-type Article (original research)
DOI 10.1002/hbm.20420
Volume 29
Issue 5
Start page 533
End page 543
Total pages 11
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract In early blindness, the primary visual area (PVA) loses the ability to process visual information, and shifts to working on the processing of somatosensory input, auditory input, and some higher-level cognitive functions. It has not yet been investigated whether such functional changes can lead to alterations of the functional connectivity between the PVA and other brain areas in resting state. The purpose of this study is to investigate the differences in the functional connectivity of the PVA between early blind and sighted subjects using resting functional MRI data. The altered functional connectivity was identified by comparing the correlation coefficients of the PVA with other brain areas between 16 early blind subjects (blindness onset within 1 year of age) and 32 gender- and age-matched healthy sighted volunteers. Compared with the sighted, the early blind subjects showed decreased functional connectivity between the left PVA and the bilateral supplementary motor area (SMA), pre- and postcentral gyri, superior parietal lobule, and the left superior and middle temporal gyri. Early blind subjects also showed decreased functional connectivity between the right PVA and the bilateral SMA, pre- and postcentral gyri. Our findings suggest that early deprivation of a single sensory modality induces alterations of functional connectivity between the deprived functional area and other associated brain areas.
Keyword Human brain
Early blindness
Resting state
Functional connectivity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 24 MAY 2007

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Thu, 20 Oct 2011, 14:44:47 EST by Debra McMurtrie on behalf of Queensland Brain Institute