Relationship between Mycobacterium tuberculosis genotype and the clinical phenotype of pulmonary and meningeal tuberculosis

Thwaites, Guy, Caws, Maxine, Chau, Tran Thi, D'Sa, Anthony, Lan, Nguyen Thi Guoc, Huyen, Mai Nguyet Thu, Gagneux, Sebastian, Anh, Phan Thi Hoanh Anh, Tho, Dau Quang, Torok, Estee, Nhu, Nguyen Thi Qyunh, Duyen, Nguyen Thi Hong, Duy, Phan Minh, Richenberg, Jonathan, Simmons, Cameron, Hien, Tran Tinh and Farrar, Jeremy (2008) Relationship between Mycobacterium tuberculosis genotype and the clinical phenotype of pulmonary and meningeal tuberculosis. Journal of Clinical Microbiology, 46 4: 1363-1368. doi:10.1128/JCM.02180-07

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Author Thwaites, Guy
Caws, Maxine
Chau, Tran Thi
D'Sa, Anthony
Lan, Nguyen Thi Guoc
Huyen, Mai Nguyet Thu
Gagneux, Sebastian
Anh, Phan Thi Hoanh Anh
Tho, Dau Quang
Torok, Estee
Nhu, Nguyen Thi Qyunh
Duyen, Nguyen Thi Hong
Duy, Phan Minh
Richenberg, Jonathan
Simmons, Cameron
Hien, Tran Tinh
Farrar, Jeremy
Title Relationship between Mycobacterium tuberculosis genotype and the clinical phenotype of pulmonary and meningeal tuberculosis
Formatted title
Relationship between Mycobacterium tuberculosis genotype and the clinical phenotype of pulmonary and meningeal tuberculosis. Error condition detected
Journal name Journal of Clinical Microbiology   Check publisher's open access policy
ISSN 0095-1137
1070-633X
1098-660X
Publication date 2008
Sub-type Article (original research)
DOI 10.1128/JCM.02180-07
Open Access Status File (Publisher version)
Volume 46
Issue 4
Start page 1363
End page 1368
Total pages 6
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Formatted abstract
We used large sequence polymorphisms to determine the genotypes of 397 isolates of Mycobacterium tuberculosis from human immunodeficiency virus-uninfected Vietnamese adults with pulmonary (n = 235) or meningeal (n = 162) tuberculosis. We compared the pretreatment radiographic appearances of pulmonary tuberculosis and the presentation, response to treatment, and outcome of tuberculous meningitis between the genotypes. Multivariate analysis identified variables independently associated with genotype and outcome. A higher proportion of adults with pulmonary tuberculosis caused by the Euro-American genotype had consolidation on chest X-ray than was the case with disease caused by other genotypes (P = 0.006). Multivariate analysis revealed that meningitis caused by the East Asian/Beijing genotype was independently associated with a shorter duration of illness before presentation and fewer cerebrospinal fluid (CSF) leukocytes. Older age, fewer CSF leukocytes, and the presence of hemiplegia (but not strain lineage) were independently associated with death or severe disability, although the East Asian/Beijing genotype was strongly associated with drug-resistant tuberculosis. The genotype of M. tuberculosis influenced the presenting features of pulmonary and meningeal tuberculosis. The association between the East Asian/Beijing lineage and disease progression and CSF leukocyte count suggests the lineage may alter the presentation of meningitis by influencing the intracerebral inflammatory response. In addition, increased drug resistance among bacteria of the East Asian/Beijing lineage might influence the response to treatment. This study suggests the genetic diversity of M. tuberculosis has important clinical consequences.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
School of Chemistry and Molecular Biosciences
 
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Created: Thu, 20 Oct 2011, 14:33:40 EST by Dr Minh Duy Phan on behalf of School of Chemistry & Molecular Biosciences