Nucleophosmin and nucleolin regulate K-Ras signaling

Inder, Kerry L., Hill, Michelle M. and Hancock, John F. (2010) Nucleophosmin and nucleolin regulate K-Ras signaling. Communicative and Integrative Biology, 3 2: 188-190. doi:10.4161/cib.3.2.10923

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Author Inder, Kerry L.
Hill, Michelle M.
Hancock, John F.
Title Nucleophosmin and nucleolin regulate K-Ras signaling
Journal name Communicative and Integrative Biology   Check publisher's open access policy
ISSN 1942-0889
Publication date 2010-03
Sub-type Article (original research)
DOI 10.4161/cib.3.2.10923
Open Access Status DOI
Volume 3
Issue 2
Start page 188
End page 190
Total pages 3
Place of publication Austin, TX, United States
Publisher Landes Bioscience
Language eng
Abstract Ras proteins are laterally segregated into transient nanoclusters on the plasma membrane, a property essential for high fidelity signal transduction through the MAPK pathway. From a proteomic screen we identified nucleophosmin (NPM) and nucleolin as two novel regulators of K-Ras plasma membrane interactions that in turn influence MAP Kinase signaling. NPM and nucleolin are predominately nucleolar proteins but also possess extra-nuclear functions. We showed that a subset of NPM and nucleolin localize to the inner leaflet of the plasma membrane and specifically interact with K-Ras but not H-Ras. This interaction is independent of the activation state of K-Ras, and stabilizes K-Ras membrane levels. NPM expression also increases the fraction of K-Ras in nanoclusters. The increase in clustered K-Ras-GTP enhances signaling through the MAPK pathway. Together these results identify NPM and nucleolin as a new class of K-Ras regulators that modulate signal transduction via the MAPK pathway.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

 
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Created: Thu, 20 Oct 2011, 14:31:46 EST by Dr Michelle Hill on behalf of School of Chemistry & Molecular Biosciences