Clinical and patient based evaluation of immunotherapy for grass pollen and mite allergy

Petersen, K. Dam, Gyrd-Hansen, D., Kjaergaard, S. and Dahl, R. (2005) Clinical and patient based evaluation of immunotherapy for grass pollen and mite allergy. Allergologia et Immunopathologia, 33 5: 264-269. doi:10.1157/13080929

Author Petersen, K. Dam
Gyrd-Hansen, D.
Kjaergaard, S.
Dahl, R.
Title Clinical and patient based evaluation of immunotherapy for grass pollen and mite allergy
Journal name Allergologia et Immunopathologia   Check publisher's open access policy
ISSN 0301-0546
Publication date 2005
Sub-type Article (original research)
DOI 10.1157/13080929
Volume 33
Issue 5
Start page 264
End page 269
Total pages 6
Place of publication Barcelona, Spain
Publisher Elsevier Doyma
Language eng
Formatted abstract
Background: Treatment of allergic disease can be done by pharmacological intervention by allergen avoidance – in the following called standard care (SC), or by specific treatment with allergy vaccination; Specific Immunotherapy (SIT). The aim of this study were to evaluate the effects of subcutaneously administrated SIT compared to SC by objective (clinical/medical records) and subjective parameters (patient's opinion) in a before/after SIT study.
Methods: The study included retrospectively all grass- and mite allergic 16-60 year old patients (N = 253) who had started SIT for grass pollen or mite allergy during the period 1.1.1996-1.1.2002 at The Allergy Unit, Aarhus University Hospital, or at a specialist practice in Aarhus. Relevant data were collected before/after treatment from medical records and from a specific designed questionnaire. The following indicators for effect were applied: Success of immunotherapy expressed as completion of up dosing phase, change in symptoms, a comparison of overall rhinoconjunctivitis symptoms, number of symptom free days per year, effect of pharmaceuticals, change in physical and psychological wellbeing and number of lost days from work/education and leisure activities.
Results: Compliance for completed up dosing for SIT was 94 % (95 % CI 90-97). The questionnaire revealed that after SIT there were a significant reduction in degree of symptoms, 84 % (95 % CI 79-89) of the respondents achieved a reduction in over all rhinoconjunctivitis score, there were an increase in symptom free days per year, a decrease in days off/incapacity from work/education and leisure activities, an improved effect of the pharmaceuticals used for allergic symptoms and an improvement in physical and psychological wellbeing. The study also showed that SIT was more effective treating rhinoconjunctivitis symptoms than lung symptoms.
Conclusion: The study revealed great advantages of SIT compared to SC and a high compliance for SIT during the up dosing period.
Keyword Allergic rhinitis
Adult persons
Grass pollen
Mite allergic
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Thu, 20 Oct 2011, 13:58:48 EST by Dorte Gyrd-hansen on behalf of Medicine - Royal Brisbane and Women's Hospital