Pathogenesis of normal-appearing white matter damage in neuromyelitis optica: Diffusion-tensor MR imaging

Yu, Chunshui, Lin, Fuchun, Li, Kuncheng, Jiang, Tianzi, Qin, Wen, Sun, Hong and Chan, Piu (2008) Pathogenesis of normal-appearing white matter damage in neuromyelitis optica: Diffusion-tensor MR imaging. Radiology, 246 1: 222-228. doi:10.1148/radiol.2461062075


Author Yu, Chunshui
Lin, Fuchun
Li, Kuncheng
Jiang, Tianzi
Qin, Wen
Sun, Hong
Chan, Piu
Title Pathogenesis of normal-appearing white matter damage in neuromyelitis optica: Diffusion-tensor MR imaging
Journal name Radiology   Check publisher's open access policy
ISSN 0033-8419
1527-1315
Publication date 2008-01
Year available 2007
Sub-type Article (original research)
DOI 10.1148/radiol.2461062075
Volume 246
Issue 1
Start page 222
End page 228
Total pages 7
Place of publication Oak Brook, IL, United States
Publisher Radiological Society of North America
Language eng
Formatted abstract
Purpose: To prospectively evaluate diffusion indexes of the corticospinal tract (CST), corpus callosum (CC), optic radiation (OR), and cingulum in patients with neuromyelitis optica (NMO) without visible lesions in the brain.
Materials and Methods: All participants provided informed consent, and the study was approved by the institutional review board. Nineteen patients with NMO (one man, 18 women; mean age, 35.1 years; range, 19–55 years) with normal brain magnetic resonance (MR) imaging findings and 19 sex- and age-matched healthy control subjects were examined with diffusion-tensor MR imaging. The CST, CC, OR, and cingulum were globally and regionally analyzed by using mean diffusivity, fractional anisotropy, and primary (λ1) and transverse (λ23) eigenvalues. Correlations of diffusion indexes of the CST and OR with the pyramidal and visual components of the Kurtzke Functional Systems (KFS) and Expanded Disability Status Scale scores were also investigated. Student t testing and Pearson correlation were performed.
Results: As compared with values in control subjects, both global and regional analyses showed significant (P < .01) increases in mean diffusivity and λ23 of the CST and OR but not in any of the diffusion indexes of the CC and cingulum in patients with NMO. In patients with NMO, mean diffusivity (r = 0.556, P = .013) and λ1 (r = 0.556, P = .013) of the CST were correlated with pyramidal KFS scores, and mean diffusivity (r = 0.523, P = .022) and λ1 (r = 0.504, P = .027) of the OR were correlated with visual KFS scores.
Conclusion: Axonal degeneration secondary to lesions in the spinal cord and optic nerves is a cause of normal-appearing white matter damage in NMO.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published online before print November 21, 2007

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Thu, 20 Oct 2011, 12:58:04 EST by Debra McMurtrie on behalf of Queensland Brain Institute