Functional disintegration in paranoid schizophrenia using resting-state fMRI

Zhou, Yuan, Liang, Meng, Tian, Lixia, Wang, Kun, Hao, Yihui, Liu, Haihong, Liu, Zhening and Jiang, Tianzi (2007) Functional disintegration in paranoid schizophrenia using resting-state fMRI. Schizophrenia Research, 97 1-3: 194-205. doi:10.1016/j.schres.2007.05.029


Author Zhou, Yuan
Liang, Meng
Tian, Lixia
Wang, Kun
Hao, Yihui
Liu, Haihong
Liu, Zhening
Jiang, Tianzi
Title Functional disintegration in paranoid schizophrenia using resting-state fMRI
Journal name Schizophrenia Research   Check publisher's open access policy
ISSN 0920-9964
1573-2509
Publication date 2007-12
Sub-type Article (original research)
DOI 10.1016/j.schres.2007.05.029
Volume 97
Issue 1-3
Start page 194
End page 205
Total pages 10
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
Functional disintegration has been observed in schizophrenia during task performance. We sought to investigate functional disintegration during rest because an intrinsic functional brain organization, including both “task-negative” (i.e., “default mode”) and “task-positive” networks, has been suggested to play an important role in integrating ongoing information processing. Additionally, the brain regions that are involved in the intrinsic organization are believed to be abnormal in schizophrenia. Patients with paranoid schizophrenia (N = 18) and healthy volunteers (N = 18) underwent a resting-state fMRI scan. Functional connectivity analysis was used to identify the connectivity between each pair of brain regions within this intrinsic organization, and differences were examined in patients versus healthy volunteers. Compared to healthy volunteers, patients showed significant differences in connectivity within networks and between networks, most notably in the connectivities associated with the bilateral dorsal medial prefrontal cortex, the lateral parietal region, the inferior temporal gyrus of the “task-negative” network and with the right dorsolateral prefrontal cortex and the right dorsal premotor cortex of the “task-positive” network. These results suggested that the interregional functional connectivities in the intrinsic organization are altered in patients with paranoid schizophrenia. These abnormalities could be the source of abnormalities in the coordination of and competition between information processing activities in the resting brain of paranoid patients.
Keyword Schizophrenia
fMRI
Resting-state
Functional connectivity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Thu, 20 Oct 2011, 12:50:58 EST by Debra McMurtrie on behalf of Queensland Brain Institute