Asymmetry of prefrontal cortical convolution complexity in males with attention-deficit/hyperactivity disorder using fractal information dimension

Li, Xiaobo, Jiang, Jiefeng, Zhu, Wanlin, Yu, Chunshui, Sui, Manqiu, Wang, Yufeng and Jiang, Tianzi (2007) Asymmetry of prefrontal cortical convolution complexity in males with attention-deficit/hyperactivity disorder using fractal information dimension. Brain and Development, 29 10: 649-655. doi:10.1016/j.braindev.2007.04.008


Author Li, Xiaobo
Jiang, Jiefeng
Zhu, Wanlin
Yu, Chunshui
Sui, Manqiu
Wang, Yufeng
Jiang, Tianzi
Title Asymmetry of prefrontal cortical convolution complexity in males with attention-deficit/hyperactivity disorder using fractal information dimension
Journal name Brain and Development   Check publisher's open access policy
ISSN 0387-7604
1872-7131
Publication date 2007-11
Sub-type Article (original research)
DOI 10.1016/j.braindev.2007.04.008
Volume 29
Issue 10
Start page 649
End page 655
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
Background and purpose: Prefrontal cortex, known to be a crucial region for the function of attention, is generally thought to be largely associated with the pathogenesis of attention-deficit hyperactivity disorder (ADHD). Most previous structural imaging studies of ADHD reported abnormality of grey matter volume in prefrontal region. However, volume measure is affected by the size of the interrogated brain, which may cause the inconsistence of the volume based findings. The purpose of the current paper is to use a scale-free measure, fractal information dimension (FID), to assess the prefrontal cortical convolution complexity and asymmetry in ADHD patients. Methods: MRI scans from 12 boys with ADHD and 11 controls were carefully processed. Prefrontal cortex was outlined manually. FIDs of bilateral prefrontal cortical surface were examined in each case. Group differences of the bilateral prefrontal cortical convolution complexities and the asymmetry pattern were statistically tested. Results: We found a left-greater-than-right prefrontal cortical convolution complexity pattern in both groups. However, compared with healthy controls, the left prefrontal cortical convolution complexities of ADHD patients were significantly reduced, resulting in significant reduction of the normal left-greater-than-right cortical convolution complexity asymmetry pattern. Conclusion: This study confirms and extends the existing anatomical knowledge about the brains of people with ADHD. The cortical convolution analysis method may also be applied to quantitatively assess changes in other neuropsychiatric syndromes as well.
Keyword Anatomic MRI
Asymmetry pattern
Attention-deficit hyperactivity disorder
Cortical convolution complexity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Thu, 20 Oct 2011, 12:45:32 EST by Debra McMurtrie on behalf of Queensland Brain Institute