Prefrontal white matter abnormalities in young adult with major depressive disorder: a diffusion tensor imaging study

Li, Lingjiang, Ma, Ning, Li, Zexuan, Tan, Liwen, Liu, Jun, Gong, Gaolang, Shu, Ni, He, Zhong, Jiang, Tianzi and Xu, Lin (2007) Prefrontal white matter abnormalities in young adult with major depressive disorder: a diffusion tensor imaging study. Brain Research, 1168 124-128. doi:10.1016/j.brainres.2007.06.094


Author Li, Lingjiang
Ma, Ning
Li, Zexuan
Tan, Liwen
Liu, Jun
Gong, Gaolang
Shu, Ni
He, Zhong
Jiang, Tianzi
Xu, Lin
Title Prefrontal white matter abnormalities in young adult with major depressive disorder: a diffusion tensor imaging study
Journal name Brain Research   Check publisher's open access policy
ISSN 0006-8993
1872-6240
Publication date 2007-07-31
Sub-type Article (original research)
DOI 10.1016/j.brainres.2007.06.094
Volume 1168
Start page 124
End page 128
Total pages 5
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
Prefrontal impairments have been hypothesized to be most strongly associated with the cognitive and emotional dysfunction in depression. Recently, white matter microstructural abnormalities in prefrontal lobe have been reported in elderly patients with major depressive disorder (MDD) using diffusion tensor imaging (DTI). However, it is still unclear whether the same changes exist in younger patients. In the present study, we first utilized DTI to detect prefrontal white matter in young adults with MDD. Nineteen first-episode, untreated young adults with MDD and twenty age- and gender-matched healthy controls were recruited. DTI and localizing anatomic data were acquired. Then, the regions of interest (ROIs) were located in prefrontal white matter at 4 mm inferior, and 0, 4, 8, 12, 16 and 20 mm superior to the anterior commissure–posterior commissure (AC–PC) plane, respectively. Compared with healthy controls, patients with MDD showed significantly lower fractional anisotropy (FA) values in prefrontal white matter at bilateral 20 mm, right 16 mm and right 12 mm above the AC–PC. Furthermore, there was no significant correlation between the FA value of any ROI and illness course as well as severity of depression. Together with previous findings, the present results suggest that microstructural abnormalities in prefrontal white matter may occur early in the course of MDD and may be related to the neuropathology of depression throughout adulthood from young to elderly.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Thu, 20 Oct 2011, 12:39:52 EST by Debra McMurtrie on behalf of Queensland Brain Institute