Altered functional connectivity in early Alzheimer's Disease: A resting-state fMRI study

Wang, Kun, Liang, Meng, Wang, Liang, Tian, Lixia, Zhang, Xinqing, Li, Kuncheng and Jiang, Tianzi (2007) Altered functional connectivity in early Alzheimer's Disease: A resting-state fMRI study. Human Brain Mapping, 28 10: 967-978. doi:10.1002/hbm.20324

Author Wang, Kun
Liang, Meng
Wang, Liang
Tian, Lixia
Zhang, Xinqing
Li, Kuncheng
Jiang, Tianzi
Title Altered functional connectivity in early Alzheimer's Disease: A resting-state fMRI study
Journal name Human Brain Mapping   Check publisher's open access policy
ISSN 1065-9471
Publication date 2007-10
Year available 2006
Sub-type Article (original research)
DOI 10.1002/hbm.20324
Volume 28
Issue 10
Start page 967
End page 978
Total pages 12
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Previous studies have led to the proposal that patients with Alzheimer's disease (AD) may have disturbed functional connectivity between different brain regions. Furthermore, recent resting-state functional magnetic resonance imaging (fMRI) studies have also shown that low-frequency (<0.08 Hz) fluctuations (LFF) of the blood oxygenation level-dependent signals were abnormal in several brain areas of AD patients. However, few studies have investigated disturbed LFF connectivity in AD patients. By using resting-state fMRI, this study sought to investigate the abnormal functional connectivities throughout the entire brain of early AD patients, and analyze the global distribution of these abnormalities. For this purpose, the authors divided the whole brain into 116 regions and identified abnormal connectivities by comparing the correlation coefficients of each pair. Compared with healthy controls, AD patients had decreased positive correlations between the prefrontal and parietal lobes, but increased positive correlations within the prefrontal lobe, parietal lobe, and occipital lobe. The AD patients also had decreased negative correlations (closer to zero) between two intrinsically anti-correlated networks that had previously been found in the resting brain. By using resting-state fMRI, our results supported previous studies that have reported an anterior–posterior disconnection phenomenon and increased within-lobe functional connectivity in AD patients. In addition, the results also suggest that AD may disturb the correlation/anti-correlation effect in the two intrinsically anti-correlated networks.
Keyword Alzheimer's disease
Low-frequency blood oxygenation level-dependent fluctuations
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 28 NOV 2006

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Thu, 20 Oct 2011, 12:04:04 EST by Debra McMurtrie on behalf of Queensland Brain Institute