White Matter Abnormalities in First-Episode, Treatment-Naive Young Adults With Major Depressive Disorder

Ma, Ning, Li, Lingjiang, Shu, Ni, Liu, Jun, Gong, Gaolang, He, Zhong, Li, Zexuan, Tan, Liwen, Stone, William S., Zhang, Zishu, Xu, Lin and Jiang, Tianzi (2007) White Matter Abnormalities in First-Episode, Treatment-Naive Young Adults With Major Depressive Disorder. The American Journal of Psychiatry, 164 5: 823-826. doi:10.1176/appi.ajp.164.5.823


Author Ma, Ning
Li, Lingjiang
Shu, Ni
Liu, Jun
Gong, Gaolang
He, Zhong
Li, Zexuan
Tan, Liwen
Stone, William S.
Zhang, Zishu
Xu, Lin
Jiang, Tianzi
Title White Matter Abnormalities in First-Episode, Treatment-Naive Young Adults With Major Depressive Disorder
Journal name The American Journal of Psychiatry   Check publisher's open access policy
ISSN 0002-953X
Publication date 2007-05-01
Sub-type Article (original research)
DOI 10.1176/appi.ajp.164.5.823
Volume 164
Issue 5
Start page 823
End page 826
Total pages 4
Place of publication Arlington, VA, United States
Publisher American Psychiatric Publishing
Language eng
Formatted abstract
OBJECTIVE: The aim of this study was to explore the microstructural integrity of whole-brain white matter by diffusion tensor imaging in first-episode, treatment-naive young adults with major depressive disorder.
METHOD: Diffusion tensor imaging scans were obtained from 14 first-episode, treatment-naive young adult patients with major depressive disorder and 14 healthy comparison subjects. A voxel-based method was used to analyze the scans.
RESULTS: The patient group exhibited significantly lower fractional anisotropy values than healthy comparison subjects in the white matter of the right middle frontal gyrus, the left lateral occipitotemporal gyrus, and the subgyral and angular gyri of the right parietal lobe. There were no regions of significantly higher fractional anisotropy values in patients compared with healthy comparison subjects.
CONCLUSIONS: These findings suggest that abnormalities of brain white matter may be present early in the course of major depressive disorder. They also support the idea that white matter lesions may disrupt the neural circuits involved in mood regulation and thus contribute to the neuropathology of major depressive disorder.


Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Thu, 20 Oct 2011, 21:43:23 EST by Debra McMurtrie on behalf of Queensland Brain Institute