Antimalarial, anticancer, antimicrobial activities and chemical constituents of essential oil from the aerial parts of Cyperus kyllingia Endl.

Khamsam, Sorachai, Liawruangrath, Boonsom, Liawruangrath, Saisunee, Teerawutkulrag, Aphiwat, Pyne, Stephen G. and Garson, Mary J. (2011) Antimalarial, anticancer, antimicrobial activities and chemical constituents of essential oil from the aerial parts of Cyperus kyllingia Endl.. Records of Natural Products, 5 4: 324-327.

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Author Khamsam, Sorachai
Liawruangrath, Boonsom
Liawruangrath, Saisunee
Teerawutkulrag, Aphiwat
Pyne, Stephen G.
Garson, Mary J.
Title Antimalarial, anticancer, antimicrobial activities and chemical constituents of essential oil from the aerial parts of Cyperus kyllingia Endl.
Formatted title
Antimalarial, anticancer, antimicrobial activities and chemical constituents of essential oil from the aerial parts of Cyperus kyllingia Endl.
Journal name Records of Natural Products   Check publisher's open access policy
ISSN 1307-6167
Publication date 2011
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 5
Issue 4
Start page 324
End page 327
Total pages 4
Place of publication Gebze-Kocaeli, Turkey
Publisher ACG Publications
Collection year 2012
Language eng
Formatted abstract
The chemical constituents of the essential oil from Cyperus kyllingia Endl. were analyzed by a GC, GC-MS. Twenty-three compounds were identified, accounting for 93.75% of the total oil that consisted mainly of oxygenated sesquiterpenes (53.52%), particularly sesquiterpene hydrocarbons (38.97%), and carboxylic acid (1.26%). The most representative compounds were α-cadinol (19.32%), caryophyllene oxide (12.17%), α-muurolol (11.58%), α-humulene (9.85%), and α-atlantone (6.07%). The oil showed significant activities against Plasmodium falcipalum (K1, multi drug resistant strain) and NCI-H187 (Small Cell Lung Cancer) with the IC50 values of 7.52 and 7.72 μg/mL, respectively. The oil exhibited highly active against Staphylococcus aureus ATCC25923 and moderately active against Escherichia coli ATCC25922, Pseudomonas aeruginosa ATCC27553, Aspergillus flavus and Candida albicans.
Keyword Cyperus kyllingia Endl.
Essential oil
Antimalarial activity
Anticancer activity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published under Short Reports

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Thu, 20 Oct 2011, 11:30:51 EST by Professor Mary Garson on behalf of School of Chemistry & Molecular Biosciences