The many faces of the flavivirus non-structural glycoprotein NS1

Muller, David and Young, Paul R. (2012). The many faces of the flavivirus non-structural glycoprotein NS1. In Pei-Yong Shi (Ed.), Molecular virology and control of flaviviruses (pp. 51-75) Norfolk, United Kingdom: Caister Academic Press.

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Name Description MIMEType Size Downloads
Author Muller, David
Young, Paul R.
Title of chapter The many faces of the flavivirus non-structural glycoprotein NS1
Title of book Molecular virology and control of flaviviruses
Place of Publication Norfolk, United Kingdom
Publisher Caister Academic Press
Publication Year 2012
Sub-type Critical review of research, literature review, critical commentary
ISBN 9781904455929
Editor Pei-Yong Shi
Chapter number 4
Start page 51
End page 75
Total pages 25
Total chapters 15
Collection year 2013
Language eng
Formatted Abstract/Summary
The Flavivirus non-structural protein, NS1 is an enigmatic protein whose structure and mechanistic function has remained elusive since it was first identified in 1970 as a viral antigen circulating in the sera of dengue infected patients. All Flavivirus NS1 genes share a high degree of homology, encoding a 352 amino acid polypeptide that has a molecular weight of between 46 and 55 kDa depending on its glycosylation status. NS1 exists in multiple oligomeric forms and is found at different cellular locations; cell membrane associated in vesicular compartments within the cell or on the cell surface and as a secreted extracellular hexamer. Intracellular NS1 plays an essential cofactor role in virus replication and has been shown to co-localize with dsRNA and other components of the viral replication complex. However the precise function of this protein in viral replication has yet to be elucidated. Secreted and cell surface associated NS1 are highly immunogenic and either the protein or the antibodies it elicits have been implicated in both protection and pathogenesis in infected hosts. It is also an important biomarker for early diagnosis. In this review we provide an overview of these disparate areas of research.
Keyword Flavivirus
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Thu, 20 Oct 2011, 09:52:20 EST by Paul Young on behalf of School of Chemistry & Molecular Biosciences