Contrast agent derived determination of the total circulating blood volume using magnetic resonance

Pannek, Kerstin, Fidler, Florian, Kartäusch, Ralf, Jakob, Peter M. and Hiller, Karl-Heinz (2011) Contrast agent derived determination of the total circulating blood volume using magnetic resonance. Magnetic Resonance Materials in Physics, Biology and Medicine, 25 3: 215-222. doi:10.1007/s10334-011-0282-7


Author Pannek, Kerstin
Fidler, Florian
Kartäusch, Ralf
Jakob, Peter M.
Hiller, Karl-Heinz
Title Contrast agent derived determination of the total circulating blood volume using magnetic resonance
Journal name Magnetic Resonance Materials in Physics, Biology and Medicine   Check publisher's open access policy
ISSN 0968-5243
1352-8661
Publication date 2011-09-18
Sub-type Article (original research)
DOI 10.1007/s10334-011-0282-7
Volume 25
Issue 3
Start page 215
End page 222
Total pages 8
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2012
Language eng
Formatted abstract
Object: Knowledge of the total circulating blood volume (TCBV) is essential for the treatment of a variety of medical conditions and blood disorders. To date, blood volume analysis is rarely carried out due to the disadvantages of available methods. Our aim was to develop a widely available, simple, fast, yet accurate method for the determination of the total circulating blood volume.

Materials and methods:
Magnetic resonance (MR) is a well-established, non-invasive technique. In this article, we present a method that uses MR contrast agents for the determination of the blood volume. The dependence of MR relaxation times on the concentration of MR contrast agents allows the calculation of the volume the contrast agent has been diluted in.

Results: In phantom and in vivo experiments we could demonstrate that TCBV can be determined with high accuracy and precision.

Conclusion: This work introduces a novel method for the determination of the total circulating blood volume using magnetic resonance contrast agents as tracers.
Keyword Total circulating blood volume
Magnetic resonance
Contrast agent
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
 
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Created: Thu, 20 Oct 2011, 19:10:33 EST by Miss Kerstin Pannek on behalf of School of Medicine