Screening of Australian plants for antimicrobial activity against Campylobacter jejuni

Kurekci, Cemil, Bishop-Hurley, Sharon L., Vercoe, Philip E., Durmic, Zoey, Al Jassim, Rafat A. M. and McSweeney, Christopher S. (2012) Screening of Australian plants for antimicrobial activity against Campylobacter jejuni. Phytotherapy Research, 26 2: 186-190. doi:10.1002/ptr.3526

Author Kurekci, Cemil
Bishop-Hurley, Sharon L.
Vercoe, Philip E.
Durmic, Zoey
Al Jassim, Rafat A. M.
McSweeney, Christopher S.
Title Screening of Australian plants for antimicrobial activity against Campylobacter jejuni
Formatted title
Screening of Australian plants for antimicrobial activity against Campylobacter jejuni
Journal name Phytotherapy Research   Check publisher's open access policy
ISSN 0951-418X
Publication date 2012-02
Year available 2011
Sub-type Article (original research)
DOI 10.1002/ptr.3526
Volume 26
Issue 2
Start page 186
End page 190
Total pages 5
Place of publication West Sussex, United Kingdom
Publisher John Wiley & Sons
Collection year 2012
Language eng
Formatted abstract
Campylobacter jejuni is a common cause of gastrointestinal illness in humans, with an annual incidence of 120 cases per 100,000 people in Australia (NNDSS Annual Report Writing Group, 2009). General symptoms of infection are bloody diarrhoea, abdominal cramps, fever and vomiting (Black et al., 1983; Gray and Pedler, 1991). In a small number of cases, post‐infection complications can include Guillain‐Barre syndrome and reactive arthritis (Nachamkin et al., 1998). C. jejuni is a Gram‐negative bacterium that inhabits the intestinal tract of a wide variety of wild and domestic animals, especially poultry (Park, 2002). This organism is frequently isolated from raw poultry meat and implicated in food poisoning in humans consuming undercooked products. The incidence of Campylobacter contamination on chicken carcasses sold in retail markets can reach 90% in Australia (Pointon et al., 2008). Furthermore, according to a case–control study, the consumption of chicken is the major risk factor and accounts for almost 30% of all campylobacteriosis in Australia (Stafford et al., 2007). While there is evidence that some control strategies, including bio‐security measures, competitive exclusion in the gut and use of bacteriophages are effective to reduce prevalence at the farm level (Gibbens et al., 2001; Stern et al., 2006; Wagenaar et al., 2005), currently, there are no sustainable strategies for reduction or elimination of this bacterium from the food chain. In addition, antibiotic resistant Campylobacter isolates have been reported worldwide (Bester and Essack, 2008; Miflin et al., 2007; Wardak et al., 2007), particularly to the quinolone group due to antibiotic usage in food animal production (Gaunt and Piddock, 1996). Thus, the health hazards associated with a high incidence of C. jejuni in retail products, as well as the persistence of antibiotic resistant C. jejuni, highlight the immediate need for new strategies to control this food‐borne pathogen. Australian medicinal plants are known to have antimicrobial activity against a range of pathogenic bacteria in humans, particularly against Gram‐positive bacteria (Palombo and Semple, 2001). However, only limited research has been done on their effect against animal pathogens, with a recent study detecting anthelmintic activity of extracts from Australian native shrubs against sheep intestinal worms (Kotze et al., 2009). The aim of this study was to evaluate the in vitro antimicrobial activity of a range of Australian plants against poultry isolates of C. jejuni, as well as some other gut pathogens, using a broth microdilution assay.
Keyword Campylobacter jejuni
Antimicrobial activity
Australian plant extracts
Minimal inhibitory concentration
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 20 MAY 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Agriculture and Food Sciences
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 20 Oct 2011, 08:46:50 EST by Dr Rafat Al Jassim on behalf of School of Agriculture and Food Sciences