Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD

Sheehan, K., Lowe, N., Kirley, A., Mullins, C., Fitzgerald, M., Gill, M. and Hawi, Z. (2005) Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD. Molecular Psychiatry, 10 10: 944-949. doi:10.1038/

Author Sheehan, K.
Lowe, N.
Kirley, A.
Mullins, C.
Fitzgerald, M.
Gill, M.
Hawi, Z.
Title Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD
Journal name Molecular Psychiatry   Check publisher's open access policy
ISSN 1359-4184
Publication date 2005-10-10
Sub-type Article (original research)
DOI 10.1038/
Volume 10
Issue 10
Start page 944
End page 949
Total pages 6
Place of publication London, United Kindgom
Publisher Nature Publishing Group
Language eng
Formatted abstract
Genetic and pharmacological studies have emphasised the role of serotonin 5-hydroxytryptamine (5-HT) as a possible etiologic factor in the development of attention-deficit hyperactivity disorder (ADHD). Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the biosynthesis of serotonin from tryptophan. Originally, the TPH gene was thought to be widely expressed, but a second form of TPH, TPH2, was recently identified and the TPH2 gene was found to be solely expressed in the brain. We examined eight single nucleotide polymorphisms (SNP) in the TPH2 gene for association with ADHD in 179 Irish nuclear families. Transmission disequilibrium test analysis revealed significant association between the T allele of marker rs1843809 with the disorder (Ξ2 = 12.2, P = 0.0006, OR = 2.36). Stratifying data by the sex of the transmitting parent showed that this association was enhanced when paternal transmission was considered (OR = 3.7). In addition, several haplotypes (all including the associated marker) were associated with ADHD. These preliminary findings suggest that TPH2 is a susceptibility locus for ADHD. Further confirmation, preferably from different ethnic groups, is required to firmly implicate TPH2 in the pathophysiology of ADHD. © 2005 Nature Publishing Group All rights reserved.
Keyword Attention-deficit hyperactivity disorder (ADHD)
Serotonergic system, genetic association
Transmission disequilibrium test (TDT)
Tryptophan hydroxylase (TPH2)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes PMID: 15940290 [PubMed - indexed for MEDLINE]

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Wed, 19 Oct 2011, 19:16:18 EST by Ziarih Hawi on behalf of Queensland Brain Institute