Beneficial effect of erythropoietin on sensorimotor function and white matter after hypoxia-ischemia in neonatal mice

Fan, Xiyong, Heijnen, Cobi J,, van der Kooij, Michael A., Groenendaal, Floris and van Bel, Frank (2011) Beneficial effect of erythropoietin on sensorimotor function and white matter after hypoxia-ischemia in neonatal mice. Pediatric Research, 69 1: 56-61. doi:10.1203/PDR.0b013e3181fcbef3

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Author Fan, Xiyong
Heijnen, Cobi J,
van der Kooij, Michael A.
Groenendaal, Floris
van Bel, Frank
Title Beneficial effect of erythropoietin on sensorimotor function and white matter after hypoxia-ischemia in neonatal mice
Journal name Pediatric Research   Check publisher's open access policy
ISSN 0031-3998
1530-0447
Publication date 2011-01
Sub-type Article (original research)
DOI 10.1203/PDR.0b013e3181fcbef3
Volume 69
Issue 1
Start page 56
End page 61
Total pages 6
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Collection year 2012
Language eng
Abstract There are mixed reports on the neuroprotective properties of erythropoietin (EPO) in animal models of birth asphyxia. We investigated the effect of EPO on short- and long-term outcome after neonatal hypoxic-ischemic (HI) brain injury in mice and compared the effect of two different dose regimens of EPO. Nine-day-old mice were subjected to HI, and EPO was injected i.p. at 0, 24, and 48 h after HI in a dose of either 5 or 20 kU/kg. Paw preference in the cylinder rearing test (CRT) was used as a measure of sensorimotor function. Only in female mice, administration of EPO at 5 kU/kg but not 20 kU/kg improved sensorimotor function, reduced striatum atrophy and hippocampal lesion volume, and enhanced myelin basic protein (MBP) staining as determined at 4 and 9 wk after HI. In addition, at 72 h after HI, more Ki67 cells were found in the subventricular zone and dentate gyrus after EPO 5 kU/kg treatment, indicating an increase in progenitor cell proliferation. In conclusion, EPO improves sensorimotor function after neonatal HI and protects against striatum atrophy, hippocampus injury, and white matter loss. The protective effect of EPO is dose-dependent and only present in females.
Keyword Dose Recombinant Erythropoietin
Brain-Injury
Neurological Function
Preterm Infants
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Non HERDC
 
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