Diffusion tensor tractography-based group mapping of the pyramidal tract in relapsing-remitting multiple sclerosis patients

Lin, Fuchun, Yu, Chunshui, Jiang, Tianzi, Li, Kuncheng and Chan, Piu (2007) Diffusion tensor tractography-based group mapping of the pyramidal tract in relapsing-remitting multiple sclerosis patients. American Journal of Neuroradiology, 28 2: 278-282.


Author Lin, Fuchun
Yu, Chunshui
Jiang, Tianzi
Li, Kuncheng
Chan, Piu
Title Diffusion tensor tractography-based group mapping of the pyramidal tract in relapsing-remitting multiple sclerosis patients
Journal name American Journal of Neuroradiology   Check publisher's open access policy
ISSN 0195-6108
1936-959X
Publication date 2007-02
Sub-type Article (original research)
Volume 28
Issue 2
Start page 278
End page 282
Total pages 5
Place of publication Oak Brook, IL, United States
Publisher American Society of Neuroradiology
Language eng
Formatted abstract
BACKGROUND AND PURPOSE: Many studies have reported abnormal changes in relapsing-remitting multiple sclerosis (RRMS) by histogram and region-of-interest-based methods by using diffusion tenor imaging. However, there are few studies on specific white matter fiber tracts of RRMS. Our study sought to use diffusion tensor tractography-based group mapping to investigate the presence of abnormal diffusion in the normal-appearing pyramidal tract (PYT) of RRMS and its possible mechanism.
METHODS: A PYT probability map was first constructed from data on 20 healthy patients based on the deterministic-based tractography method. The PYT probability map was then applied to 29 RRMS patients to calculate diffusion indices of the PYT. In this study, 4 quantitative indices-fractional anisotropy (FA), directionally averaged diffusion coefficient (Dav), axial diffusion coefficient (λ1), and radial diffusion coefficient (λ23) -were used to characterize the abnormal diffusion.
RESULTS: Compared with healthy controls, RRMS patients had a significantly higher Dav and λ23 but a lower FA and a trend toward a lower λ1 in the normal-appearing PYT. In RRMS patients, PYT lesions had a significantly higher λ23 and a lower FA, but there were no differences for Dav and λ1 when compared with the normal-appearing PYT. Moreover, the diffusion indices derived from the normal-appearing PYT were significantly correlated with PYT lesion volumes by using the Spearman correlation analysis.
CONCLUSION: Our findings confirm the presence of abnormal diffusion in the normal-appearing PYT of RRMS patients and suggest that wallerian degeneration might be its mechanism.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Wed, 19 Oct 2011, 15:44:19 EST by Debra McMurtrie on behalf of Queensland Brain Institute