Handedness-related functional connectivity using low-frequency blood oxygenation level-dependent fluctuations

He, Yong, Zang, Yufeng, Jiang, Tianzi, Gong, Gaolang, Xie, Sheng and Xiao, Jiangxi (2006) Handedness-related functional connectivity using low-frequency blood oxygenation level-dependent fluctuations. Neuroreport, 17 1: 5-8. doi:10.1097/01.wnr.0000192737.92911.a4


Author He, Yong
Zang, Yufeng
Jiang, Tianzi
Gong, Gaolang
Xie, Sheng
Xiao, Jiangxi
Title Handedness-related functional connectivity using low-frequency blood oxygenation level-dependent fluctuations
Journal name Neuroreport   Check publisher's open access policy
ISSN 0959-4965
1473-558X
Publication date 2006-01-23
Sub-type Article (original research)
DOI 10.1097/01.wnr.0000192737.92911.a4
Volume 17
Issue 1
Start page 5
End page 8
Total pages 4
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract Functional neuroimaging studies of handedness have traditionally focused on exploring regionally activated discrepancies, yet little is known regarding the effect of handedness on functional connections of brain regions. Here, we reported the relationship between cerebellar functional connectivity patterns and handedness by low-frequency blood oxygenation level-dependent fluctuations. Compared with the right-handers, the left-handers show higher cerebellar-prefrontal, cerebellar-parietal, and cerebellar-temporal functional connectivity, and lower cerebellar-limbic connectivity. Previous non-human primate studies have shown that these regions with known contributions to higher cognitive functions have afferent or efferent connections with the cerebellum. Our findings suggest that these observed low-frequency fluctuation correlations may reflect actually anatomic connections between the cerebellum and cerebral cortex, and the cerebellar involvement in higher function may be associated with handedness.
Keyword Blood oxygenation level-dependent
Cerebellum
Functional connectivity
Functional magnetic resonance imaging
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Wed, 19 Oct 2011, 21:28:32 EST by Debra McMurtrie on behalf of Queensland Brain Institute