Comparing 3 methods of monitoring gentamicin concentrations in patients with febrile neutropenia

Avent, Minyon L., Teoh, JunLu, Lees, Judith, Eckert, Kerena A. and Kirkpatrick, Carl M. (2011) Comparing 3 methods of monitoring gentamicin concentrations in patients with febrile neutropenia. Therapeutic Drug Monitoring, 33 5: 592-601. doi:10.1097/FTD.0b013e31822c78e9

Author Avent, Minyon L.
Teoh, JunLu
Lees, Judith
Eckert, Kerena A.
Kirkpatrick, Carl M.
Title Comparing 3 methods of monitoring gentamicin concentrations in patients with febrile neutropenia
Journal name Therapeutic Drug Monitoring   Check publisher's open access policy
ISSN 0163-4356
Publication date 2011-10
Sub-type Article (original research)
DOI 10.1097/FTD.0b013e31822c78e9
Volume 33
Issue 5
Start page 592
End page 601
Total pages 10
Place of publication United States
Publisher Lippincott Williams & Wilkins
Collection year 2012
Language eng
Abstract Several nomograms and algorithms have been developed to individualize pharmacokinetic monitoring with their own advantages and disadvantages. This study compared 3 pharmacokinetic methods for predicting doses and monitoring of gentamicin in adult patients with febrile neutropenia. A retrospective study of 75 patients with febrile neutropenia was conducted at the Royal Adelaide Hospital, South Australia. Each patient received a course of once-daily gentamicin and had 2 sets of paired gentamicin serum concentrations. Pharmacokinetic parameters and ensuing doses were compared using 3 pharmacokinetic methods: (1) sequential Bayesian algorithm for gentamicin (SeBA-GEN), (2) Sawchuk-Zaske, and (3) Therapeutic Guidelines: Antibiotic Dose Adjustment Nomogram. The initial median (range) dose of gentamicin administered was 400 (240-640) mg. SeBA-GEN and Sawchuk-Zaske methods recommended similar subsequent gentamicin dose adjustments of 400 (280-640) mg and 400 (280-640) mg, respectively, whereas the Therapeutic Guidelines recommended an increase to 1390 (210-6240) mg. For the Therapeutic Guidelines, 64% of the patients had measured serum gentamicin concentrations that were below the minimum line of the nomogram for the first set of concentrations with only 32% of these patients having an area under the curve value of <70 mg h/L as calculated by SeBA-GEN. The SeBA-GEN method showed a statistically significant increase (68%-77%) in patients attaining the target concentrations of maximum concentration (Cmax) 15-25 mg/L compared with the Sawchuk-Zaske method (72%-65%, P > 0.05). SeBA-GEN also demonstrated greater precision in predicting the area under the curve, Cmax, and minimum concentration (Cmin) compared with the Sawchuk-Zaske method. In conclusion, as the Bayesian approach, that is, SeBA-GEN demonstrated greater precision and more patients were attaining the target concentrations, it is therefore the preferred method for gentamicin monitoring in patients with febrile neutropenia.
Keyword Aminoglycoside nomograms
Computerized dose prediction
Pharmacokinetic methods
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2012 Collection
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 19 Oct 2011, 10:24:11 EST by Minyon Avent on behalf of UQ Centre for Clinical Research