Elevated dietary intake of Zn-methionate is associated with increased sperm DNA fragmentation in the boar

Garcia-Contreras, Adelfa, De Loera, Yasmin, Garcia-Artiga, Carlos, Palomo, Antonio, Guevara, Jesús A., Herrera-Haro, José, Lopez-Fernandez, Carmen, Johnston, Steve and Gosalvez, Jaime (2011) Elevated dietary intake of Zn-methionate is associated with increased sperm DNA fragmentation in the boar. Reproductive Toxicology, 31 4: 570-573. doi:10.1016/j.reprotox.2010.12.003


Author Garcia-Contreras, Adelfa
De Loera, Yasmin
Garcia-Artiga, Carlos
Palomo, Antonio
Guevara, Jesús A.
Herrera-Haro, José
Lopez-Fernandez, Carmen
Johnston, Steve
Gosalvez, Jaime
Title Elevated dietary intake of Zn-methionate is associated with increased sperm DNA fragmentation in the boar
Journal name Reproductive Toxicology   Check publisher's open access policy
ISSN 0890-6238
Publication date 2011-05
Sub-type Article (original research)
DOI 10.1016/j.reprotox.2010.12.003
Volume 31
Issue 4
Start page 570
End page 573
Total pages 4
Place of publication United States
Publisher Elsevier Inc.
Collection year 2012
Language eng
Abstract Boars fed on ration of 200 ppm Zn methionate showed a significant increase (P<0.001) in sperm DNA fragmentation when compared to animals fed on non-supplemented and rations containing 150 ppm Zn methionate. There was a positive correlation (R2 = 0.207; P= 0.002) between % sperm DNA fragmentation (SDF) and the concentration of Zn in spermatozoa. Increased Zn in the diet also resulted in a non-proportional increase in Zn concentration in the testis and spermatozoa but not in the epididymis; Zn in sperm accumulated at levels up to 50 times higher than that found in the seminal plasma and 10-13 times that found in the epididymis and testis, respectively. These results show that supplementation of dietary Zn at a concentration of 200 ppm had an adverse effect on boar sperm DNA quality and may be related to the ability of spermatozoa to accumulate Zn during spermiogenesis.
Keyword Cytotoxicity
Dietary Zn
Sperm chromatin damage
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Agriculture and Food Sciences
 
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Created: Wed, 19 Oct 2011, 09:37:03 EST by Associate Professor Stephen Johnston on behalf of School of Animal Studies