Echinacea alkylamides modulate induced immune responses in T-cells

Matthias, Anita, Banbury, Linda, Bone, Kerry M., Leach, David N. and Lehmann, Reg P. (2008) Echinacea alkylamides modulate induced immune responses in T-cells. Fitoterapia, 79 1: 53-58. doi:10.1016/j.fitote.2007.07.012

Author Matthias, Anita
Banbury, Linda
Bone, Kerry M.
Leach, David N.
Lehmann, Reg P.
Title Echinacea alkylamides modulate induced immune responses in T-cells
Formatted title
Echinacea alkylamides modulate induced immune responses in T-cells
Journal name Fitoterapia   Check publisher's open access policy
ISSN 1971-551X
Publication date 2008-01
Year available 2007
Sub-type Article (original research)
DOI 10.1016/j.fitote.2007.07.012
Volume 79
Issue 1
Start page 53
End page 58
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
The effects of Echinacea and several of its phytochemical components on NFκB expression by Jurkat cells (a human T-cell line) were investigated in vitro. In the absence of stimulation, Echinacea and its components exerted no significant effect on basal NFκB expression levels. In the presence of endotoxin (LPS), NFκB expression was decreased. However, this decrease was significantly reversed by treatment with cichoric acid, an Echinacea root extract (prepared from both Echinacea angustifolia and Echinacea purpurea) and the alkylamide fraction derived from this combination. For the phorbol myristate acetate stimulation of Jurkat cells, effects on NFκB expression were mixed. Depending on the concentration, cichoric acid and a 2,4-diene alkylamide significantly induced NFκB levels, whereas a 2-ene alkylamide caused a significant inhibition. In contrast, both the Echinacea and the mixed alkylamide fraction exerted no effect. The alkylamide results indicate that the two basic forms of these compounds present in Echinacea may have opposing effects. These opposing effects demonstrate the importance of a knowledge, not only of the phytochemical make-up of a herbal preparation, but also of the actions of each component and the consequences of differing relative amounts in the preparation being investigated.
Keyword Echinacea angustifolia
Echinacea purpurea
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Available online 11 August 2007

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 25 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 19 Oct 2011, 08:55:22 EST by Anita Matthias on behalf of School of Biomedical Sciences