Investigations into the antiadhesive activity of herbal extracts against Campylobacter jejuni

Bensch, K., Tiralongo, J., Schmidt, K., Matthias, A., Bone, K. M., Lehmann, R. and Tiralongo, E. (2011) Investigations into the antiadhesive activity of herbal extracts against Campylobacter jejuni. Phytotherapy Research, 25 8: 1125-1132. doi:10.1002/ptr.3384


Author Bensch, K.
Tiralongo, J.
Schmidt, K.
Matthias, A.
Bone, K. M.
Lehmann, R.
Tiralongo, E.
Title Investigations into the antiadhesive activity of herbal extracts against Campylobacter jejuni
Formatted title
Investigations into the antiadhesive activity of herbal extracts against Campylobacter jejuni
Journal name Phytotherapy Research   Check publisher's open access policy
ISSN 0951-418X
1099-1573
Publication date 2011-01-31
Sub-type Article (original research)
DOI 10.1002/ptr.3384
Volume 25
Issue 8
Start page 1125
End page 1132
Total pages 8
Place of publication West Sussex, United Kingdom
Publisher John Wiley
Collection year 2012
Language eng
Formatted abstract
Campylobacter jejuni is one of the most common bacterial causes of diarrhoea in the industrialized world, being associated with the occurrence of Guillain‐Barré Syndrome, and inducing diseases partially through intestinal adherence. With increasing reports of C. jejuni drug resistance against standard antibiotics, investigations into antiadhesive agents for the prevention of bacterial infection are highly significant. Given the consumer‐driven development towards holistic and integrative healthcare, research into additional anti‐Campylobacter effects of herbal medicines that are already used for their beneficial effects on bowel and digestive functions is important.
Twenty‐one herbal extracts were screened for antiadhesive activity against C. jejuni using modifications of previously published antiadhesion assays. Antiadhesion effects with IC50 values <3 mg/mL were obtained for seven ethanol plant extracts, with Zingiber officinale (ginger), Capsicum annum (cayenne) and Glycyrrhiza glabra (licorice) displaying the highest antiadhesion activity against C. jejuni (IC50: <0.1 mg/mL, 0.29 mg/mL and 0.65 mg/mL, respectively). Differences in antiadhesion activity were found for two different Echinacea species, with E. purpurea displaying significantly higher and dose dependent antiadhesion activity than E. angustifolia. No significant antiadhesion activity (IC50 values >35 mg/mL) was found for Agrimonia eupatoria (agrimony), Andrographis paniculata (andrographis), Matricaria recutita (chamomile), Foeniculum vulgare (fennel), Filipendula ulmaria (meadowsweet) and Artemisia absinthium (wormwood) extracts.  This study provides evidence for additional beneficial effects of marketed herbal medicines in gastrointestinal disorders.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Biomedical Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 19 Oct 2011, 08:36:47 EST by Anita Matthias on behalf of School of Biomedical Sciences