Transposition and intermingling of G alpha i2 and G alpha o afferences into single vomeronasal glomeruli in the Madagascan lesser tenrec Echinops telfairi

Suarez, Rodrigo, Villalon, Aldo, Kunzle, Heinz and Mpodozis, Jorge (2009) Transposition and intermingling of G alpha i2 and G alpha o afferences into single vomeronasal glomeruli in the Madagascan lesser tenrec Echinops telfairi. PLoS One, 4 11: . doi:10.1371/journal.pone.0008005


Author Suarez, Rodrigo
Villalon, Aldo
Kunzle, Heinz
Mpodozis, Jorge
Title Transposition and intermingling of G alpha i2 and G alpha o afferences into single vomeronasal glomeruli in the Madagascan lesser tenrec Echinops telfairi
Formatted title
Transposition and intermingling of Gαi2 and Gαo afferences into single vomeronasal glomeruli in the Madagascan lesser tenrec Echinops telfairi
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2009-11-24
Sub-type Article (original research)
DOI 10.1371/journal.pone.0008005
Open Access Status DOI
Volume 4
Issue 11
Total pages 6
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Formatted abstract
The vomeronasal system (VNS) mediates pheromonal communication in mammals. From the vomeronasal organ, two populations of sensory neurons, expressing either Gαi2 or Gαo proteins, send projections that end in glomeruli distributed either at the rostral or caudal half of the accessory olfactory bulb (AOB), respectively. Neurons at the AOB contact glomeruli of a single subpopulation. The dichotomic segregation of AOB glomeruli has been described in opossums, rodents and rabbits, while Primates and Laurasiatheres present the Gαi2-pathway only, or none at all (such as apes, some bats and aquatic species). We studied the AOB of the Madagascan lesser tenrec Echinops telfairi (Afrotheria: Afrosoricida) and found that Gαi2 and Gαo proteins are expressed in rostral and caudal glomeruli, respectively. However, the segregation of vomeronasal glomeruli at the AOB is not exclusive, as both pathways contained some glomeruli transposed into the adjoining subdomain. Moreover, some glomeruli seem to contain intermingled afferences from both pathways. Both the transposition and heterogeneity of vomeronasal afferences are features, to our knowledge, never reported before. The organization of AOB glomeruli suggests that synaptic integration might occur at the glomerular layer. Whether intrinsic AOB neurons may make synaptic contact with axon terminals of both subpopulations is an interesting possibility that would expand our understanding about the integration of vomeronasal pathways.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article # e8005

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Wed, 19 Oct 2011, 02:12:17 EST by Rodrigo Suarez on behalf of Queensland Brain Institute