Effect of Y1 receptor deficiency on motor activity, exploration and anxiety

Karl, Tim, Burne, Thomas H. J. and Herzog, Herbert (2006) Effect of Y1 receptor deficiency on motor activity, exploration and anxiety. Behavioural Brain Research, 167 1: 87-93. doi:10.1016/j.bbr.2005.08.019


Author Karl, Tim
Burne, Thomas H. J.
Herzog, Herbert
Title Effect of Y1 receptor deficiency on motor activity, exploration and anxiety
Formatted title
Effect of Y1 receptor deficiency on motor activity, exploration and anxiety
Journal name Behavioural Brain Research   Check publisher's open access policy
ISSN 0166-4328
1872-7549
Publication date 2006-02-15
Year available 2005
Sub-type Article (original research)
DOI 10.1016/j.bbr.2005.08.019
Volume 167
Issue 1
Start page 87
End page 93
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
Neuropeptide Y (NPY) in the CNS plays an important regulatory role in anxiety-related responses as exogenous administration of NPY exerts an anxiolytic-like effect in rodents. This effect is believed to be mediated by the Y1 receptor system as pharmacological modulation of this Y1 receptor system results in an increase in anxiety. Here we present a comprehensive phenotyping strategy for characterizing Y1 receptor knockout animals at different times of the circadian rhythm using several motor activity-, exploration-, and anxiety-related behavioural tasks including open field, elevated plus maze, light–dark, and hole board test. We show that Y1 deficiency has an important effect on motor activity and explorative-like behaviours and that it results in marked alterations in anxiety-related behaviours. Importantly, the behavioural phenotype of the Y1 receptor knockout mice is circadian rhythm-dependent and also influenced by stimuli such as restraint stress. In addition, we found evidence for increases in working memory. Taken together, these findings suggest an important role of Y1 receptors in the regulation of motor activity, exploration, and anxiety-related behaviours. This role is also influenced by several factors such as circadian rhythm and stress exposure confirming the importance of a comprehensive strategy and of using genetic animal models in behavioural neuroscience.
Keyword Mouse
NPY
Y1 receptor
Motor activity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Available online 3 October 2005

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
ERA 2012 Admin Only
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 58 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 61 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 18 Oct 2011, 22:46:29 EST by Dr Thomas Burne on behalf of Queensland Brain Institute