Formaldehyde stress

He, Rong-Qiao, Lu, Jing and Miao, Jun-Ye (2010) Formaldehyde stress. Science China Life Sciences, 53 12: 1399-1404. doi:10.1007/s11427-010-4112-3

Author He, Rong-Qiao
Lu, Jing
Miao, Jun-Ye
Title Formaldehyde stress
Journal name Science China Life Sciences   Check publisher's open access policy
ISSN 1674-7305
Publication date 2010-12-23
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11427-010-4112-3
Open Access Status DOI
Volume 53
Issue 12
Start page 1399
End page 1404
Total pages 6
Place of publication Beijing, China
Publisher Zhongguo Kexue Zazhishe
Language eng
Formatted abstract
Formaldehyde, one of the most toxic organic compounds, is produced and processed in human cells. The level of human endogenous formaldehyde is maintained at a low concentration (0.01-0.08 mmol L-1 in blood) under physiological conditions, but the concentration increases during ageing (over 65 years old). Clinical trials have shown that urine formaldehyde concentrations are significantly different between elderly Alzheimer's patients (n=91) and normal elderly volunteers (n=38) (P<0.001). Abnormally high levels of intrinsic formaldehyde lead to dysfunction in cognition such as learning decline and memory loss. Excess extracellular and intracellular formaldehyde could induce metabolic response and abnormal modifications of cellular proteins such as hydroxymethylation and hyperphosphorylation, protein misfolding, nuclear translocation and even cell death. This cellular response called formaldehyde stress is dependent upon the concentration of formaldehyde. Chronic impairments of the brain resulted from formaldehyde stress could be one of the mechanisms involved in the process of senile dementia during ageing. © 2010 Science China Press and Springer-Verlag Berlin Heidelberg.
Keyword Alzheimer's disease
Senile Dementia
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 44 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 18 Oct 2011, 11:56:22 EST by Jing Lu on behalf of Queensland Brain Institute