Fetal loss and hyposulfataemia in pregnant NaS1 transporter null mice

Dawson, Paul A., Sim, Pearl, Simmons, David G. and Markovich, Daniel (2011) Fetal loss and hyposulfataemia in pregnant NaS1 transporter null mice. Journal of Reproduction and Development, 57 4: 444-449. doi:10.1262/jrd.10-173K


Author Dawson, Paul A.
Sim, Pearl
Simmons, David G.
Markovich, Daniel
Title Fetal loss and hyposulfataemia in pregnant NaS1 transporter null mice
Journal name Journal of Reproduction and Development   Check publisher's open access policy
ISSN 0916-8818
1348-4400
Publication date 2011-08
Sub-type Article (original research)
DOI 10.1262/jrd.10-173K
Open Access Status DOI
Volume 57
Issue 4
Start page 444
End page 449
Total pages 6
Place of publication Tokyo, Japan
Publisher Japanese Society of Animal Reproduction
Collection year 2012
Language eng
Formatted abstract
Sulfate is important for growth and development, and is supplied from mother to fetus throughout pregnancy. We used NaS1 sulfate transporter null (Nas1-/-) mice to investigate the role of NaS1 in maintaining sulfate homeostasis during pregnancy and to determine the physiological consequences of maternal hyposulfataemia on fetal, placental and postnatal growth. We show that maternal serum (≤0.5 mM), fetal serum (<0.1 mM) and amniotic fluid (≤0.5 mM) sulfate levels were significantly lower in pregnant Nas1-/- mice when compared with maternal serum (≈2.0 mM), fetal serum (≈1.5 mM) and amniotic fluid (≈1.7 mM) sulfate levels in pregnant Nas1+/+ mice. After 12 days of pregnancy, fetal reabsorptions led to markedly reduced (by ≥50%) fetal numbers in Nas1-/- mice. Placental labyrinth and spongiotrophoblast layers were increased (by ≈140%) in pregnant Nas1-/- mice when compared to pregnant Nas1+/+ mice. Birth weights of progeny from female Nas1-/- mice were increased (by ≈7%) when compared to progeny of Nas1+/+ mice. These findings show that NaS1 is essential to maintain high maternal and fetal sulfate levels, which is important for maintaining pregnancy, placental development and normal birth weight.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biomedical Sciences Publications
 
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Created: Tue, 18 Oct 2011, 10:17:10 EST by Bacsweet Kaur on behalf of School of Biomedical Sciences