Treatment of articulatory dysfunction in Parkinson’s disease using repetitive transcranial magnetic stimulation

Murdoch, B. E., Ng, M. L. and Barwood, C. H. S. (2012) Treatment of articulatory dysfunction in Parkinson’s disease using repetitive transcranial magnetic stimulation. European Journal of Neurology, 19 2: 340-347.


Author Murdoch, B. E.
Ng, M. L.
Barwood, C. H. S.
Title Treatment of articulatory dysfunction in Parkinson’s disease using repetitive transcranial magnetic stimulation
Journal name European Journal of Neurology  (ERA 2012 Listed)    (ERA 2010 Rank B)   Check publisher's open access policy
Publication date 2012-02
Sub-type Article
Year available 2011
DOI 10.1111/j.1468-1331.2011.03524.x
Volume number 19
Issue number 2
ISSN 1351-5101; 1468-1331
Start page 340
End page 347
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell
Collection year 2012
Language eng
Formatted abstract Background and purpose:
Neuroimaging has demonstrated that improved speech outcomes in Parkinson’s Disease (PD) subsequent to behavioural treatment approaches are associated with increased activity in the motor and pre-motor cortex. High-frequency repetitive transcranial magnetic stimulation (rTMS) is capable of modulating cortical activity and has been reported to have significant benefit to general motor function in PD. It is possible that high-frequency rTMS may also have beneficial outcomes on speech production in PD.

Methods:
High-frequency (5 Hz) rTMS was applied to 10 active stimulation and 10 sham placebo patients for 10 min/day (3000 pulses), for 10 days and speech outcome measures and lingual kinematic parameters recorded at baseline and 1 week, 2 and 12 months post-stimulation.

Results: 
The findings demonstrated positive treatment-related changes observed in the active rTMS group when compared to the sham placebo control group at 2 and 12 months post-stimulation in speech intelligibility, communication efficiency ratio, maximum velocity of tongue movements and distance of tongue movements.

Conclusion: 
The results support the use of high-frequency rTMS as a therapeutic tool for the treatment of articulatory dysfunction in PD.
Keyword Dysarthria
Parkinson’s disease
Transcranial magnetic stimulation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 4 October 2011.

Document type: Journal Article
Sub-type: Article
Collections: Official 2013 Collection
School of Health and Rehabilitation Sciences Publications
 
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Created: Tue, 18 Oct 2011, 10:13:07 EST by Professor Bruce Murdoch on behalf of School of Health & Rehabilitation Sciences