Omega-3 fatty acids and metabolic syndrome: Effects and emerging mechanisms of action

Poudyal, Hemant, Panchal, Sunil K., Diwan, Vishal and Brown, Lindsay (2011) Omega-3 fatty acids and metabolic syndrome: Effects and emerging mechanisms of action. Progress in Lipid Research, 50 4: 372-387. doi:10.1016/j.plipres.2011.06.003

Author Poudyal, Hemant
Panchal, Sunil K.
Diwan, Vishal
Brown, Lindsay
Title Omega-3 fatty acids and metabolic syndrome: Effects and emerging mechanisms of action
Journal name Progress in Lipid Research   Check publisher's open access policy
ISSN 0163-7827
Publication date 2011-10-04
Sub-type Article (original research)
DOI 10.1016/j.plipres.2011.06.003
Volume 50
Issue 4
Start page 372
End page 387
Total pages 16
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2012
Language eng
Formatted abstract
Epidemiological, human, animal, and cell culture studies show that n−3 fatty acids, especially α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), reduce the risk factors of cardiovascular diseases. EPA and DHA, rather than ALA, have been the focus of research on the n−3 fatty acids, probably due to the relatively inefficient conversion of ALA to EPA and DHA in rodents and humans. This review will assess our current understanding of the effects and potential mechanisms of actions of individual n−3 fatty acids on multiple risk factors of metabolic syndrome. Evidence for pharmacological responses and the mechanism of action of each of the n−3 fatty acid trio will be discussed for the major risk factors of metabolic syndrome, especially adiposity, dyslipidemia, insulin resistance and diabetes, hypertension, oxidative stress, and inflammation. Metabolism of n−3 and n−6 fatty acids as well as the interactions of n−3 fatty acids with nutrients, gene expression, and disease states will be addressed to provide a rationale for the use of n−3 fatty acids to reduce the risk factors of metabolic syndrome.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biomedical Sciences Publications
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Created: Mon, 17 Oct 2011, 15:45:05 EST by Bacsweet Kaur on behalf of School of Biomedical Sciences