Stearoyl-CoA desaturase: A vital checkpoint in the development and progression of obesity

Poudyal, Hemant and Brown, Lindsay (2011) Stearoyl-CoA desaturase: A vital checkpoint in the development and progression of obesity. Endocrine, Metabolic and Immune Disorders - Drug Targets, 11 3: 217-231. doi:10.2174/187153011796429826

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Author Poudyal, Hemant
Brown, Lindsay
Title Stearoyl-CoA desaturase: A vital checkpoint in the development and progression of obesity
Journal name Endocrine, Metabolic and Immune Disorders - Drug Targets   Check publisher's open access policy
ISSN 1871-5303
2212-3873
Publication date 2011-09
Sub-type Article (original research)
DOI 10.2174/187153011796429826
Volume 11
Issue 3
Start page 217
End page 231
Total pages 15
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2012
Language eng
Abstract Stearoyl-CoA desaturase 1 (SCD-1) is the rate-limiting enzyme that catalyses the conversion of saturated to monounsaturated fatty acids. Increased SCD-1 expression and activity have been implicated in cancer, cardiovascular diseases, insulin resistance and obesity. Studies with humans, wild-type rodents, knock-out mice and cells in culture show that SCD-1 inhibition decreases lipogenesis and increases GLUT4-mediated glucose uptake in skeletal muscle. In this review, we will evaluate the role of SCD-1 as a homeostatic check-point between glucose and fatty acid metabolism in the development and progression of obesity. In addition to the role of SCD-1 in glucose and fatty acid metabolism, we will also discuss the expression and regulation of SCD-1, its specific interactions with inflammatory responses and PPARs, the role of SCD-1 derived MUFAs in obesity and the relevance of SCD desaturation index as a predictor of obesity and metabolic syndrome. Additionally, we will explore the prospects of SCD-1 as a potential drug target for the management of obesity and related disorders.
Keyword Stearoyl-CoA desaturase
SCD-1
Metabolic syndrome
PPAR
Desaturation index
MUFA
Obesity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biomedical Sciences Publications
 
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Created: Mon, 17 Oct 2011, 15:06:20 EST by Bacsweet Kaur on behalf of School of Biomedical Sciences