Regulation of expression of secretory leukocyte protease inhibitor by progesterone in BeWo choriocarcinoma cells

Sidharthan, Neelima P. and Jagannadha Rao, Addicam (2011) Regulation of expression of secretory leukocyte protease inhibitor by progesterone in BeWo choriocarcinoma cells. Journal of Steroids and Hormonal Science, 2 2: 1000107.1-1000107.4. doi:10.4172/2157-7536.1000107

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Author Sidharthan, Neelima P.
Jagannadha Rao, Addicam
Title Regulation of expression of secretory leukocyte protease inhibitor by progesterone in BeWo choriocarcinoma cells
Journal name Journal of Steroids and Hormonal Science   Check publisher's open access policy
ISSN 2157-7536
Publication date 2011-07-29
Sub-type Article (original research)
DOI 10.4172/2157-7536.1000107
Volume 2
Issue 2
Start page 1000107.1
End page 1000107.4
Total pages 4
Place of publication Los Angeles, CA, United States
Publisher OMICS Publishing Group
Collection year 2012
Language eng
Abstract Secretory leukocyte protease inhibitor is a multifunctional protein with a variety of activities attributed to it. A significant increase in the expression of Secretory leukocyte protease inhibitor was noticed in syncytiotrophoblasts following differentiation of cytotrophoblasts in to syncytiotrophoblasts by addition of Forskolin. Using the BeWo cells which are derived from choriocarcinoma, the effect of addition of progesterone and estradiol on the expression of Secretory leukocyte protease inhibitor by Reverse Transcription Polymerase Chain Reaction was assessed. It was found that while addition of low concentration of progesterone resulted in a significant increase in expression of Secretory leukocyte protease inhibitor, addition of estradiol even at high concentration had no effect. The specificity of effect of progesterone was established by the observation that addition of Progesterone along with progesterone receptor antagonist (RU484) resulted in decrease in the level of expression of Secretory leukocyte protease inhibitor. These results suggest that Secretory protease leukocyte protease inhibitor is a progesterone regulated gene.
Keyword Progesterone
Estrogen
Regulation
SLPI
BeWo cells
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Biomedical Sciences Publications
 
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Created: Mon, 17 Oct 2011, 14:58:21 EST by Neelima Pottekkat Sidharthan on behalf of School of Biomedical Sciences