TRbase: a database relating tandem repeats to disease genes for the human genome

Boby, T., Patch, A.-M. and Aves, S. J. (2005) TRbase: a database relating tandem repeats to disease genes for the human genome. Bioinformatics, 21 6: 811-816. doi:10.1093/bioinformatics/bti059

Author Boby, T.
Patch, A.-M.
Aves, S. J.
Title TRbase: a database relating tandem repeats to disease genes for the human genome
Journal name Bioinformatics   Check publisher's open access policy
ISSN 1367-4803
Publication date 2005-03
Year available 2004
Sub-type Article (original research)
DOI 10.1093/bioinformatics/bti059
Volume 21
Issue 6
Start page 811
End page 816
Total pages 6
Place of publication Oxford, U. K.
Publisher Oxford University Press
Language eng
Formatted abstract
Motivation: Tandem repeats are associated with disease genes, play an important role in evolution and are important in genomic organization and function. Although much research has been done on short perfect patterns of repeats, there has been less focus on imperfect repeats. Thus, there is an acute need for a tandem repeats database that provides reliable and up to date information on both perfect and imperfect tandem repeats in the human genome and relates these to disease genes.
Results: This paper presents a web-accessible relational tandem repeats database that relates tandem repeats to gene locations and disease genes of the human genome. In contrast to other available databases, this database identifies both perfect and imperfect repeats of 1–2000 bp unit lengths. The utility of this database has been illustrated by analysing these repeats for their distribution and frequencies across chromosomes and genomic locations and between proteincoding and non-coding regions. The applicability of this database to identify diseases associated
Keyword Simple sequence repeats
Huntingtons disease
DNA sequences
Cag repeat
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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